Status	Stage
New Updated	Protocol Review

• Abatacept for rheumatoid arthritis
• Acetaminophen for osteoarthritis
• Acupuncture and electroacupuncture for the treatment of rheumatoid arthritis
• Acupuncture for hip osteoarthritis
• Acupuncture for lateral elbow pain
• Acupuncture for peripheral joint osteoarthritis
• Acupuncture for shoulder pain
• Acupuncture for treating fibromyalgia
• Adalimumab for treating rheumatoid arthritis
• Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee
• Adrenocorticotropic hormone for acute gout
• Adverse effects of biologics: a network meta-analysis and Cochrane overview
• Aerobic exercise training for adults with fibromyalgia
• Allopurinol for chronic gout
• Anakinra for rheumatoid arthritis
• Anti-cytokine targeted therapies for ANCA-associated vasculitis
• Anti-interferon therapy for systemic lupus erythematosus
• Anti-sclerostin antibodies for the treatment of osteoporosis
• Antibiotics for reactive arthritis
• Antidepressants for hip and knee osteoarthritis
• Antidepressants for pain management in rheumatoid arthritis
• Antimalarials for treating rheumatoid arthritis
• Aquatic exercise for the treatment of knee and hip osteoarthritis
• Aquatic exercise training for fibromyalgia
• Aquatic therapy exercise for treating rheumatoid arthritis
• Arthrographic distension for adhesive capsulitis (frozen shoulder)
• Arthroscopic debridement for knee osteoarthritis
• Arthroscopic surgery for degenerative knee disease (osteoarthritis including degenerative meniscal tears)
• Assistive devices, hip precautions, environmental modifications and training to prevent dislocation and improve function after hip arthroplasty
• Assistive technology for rheumatoid arthritis
• Auranofin versus placebo in rheumatoid arthritis
• Autologous blood and platelet-rich plasma injection therapy for lateral elbow pain
• Autologous blood product injections including platelet-rich plasma for osteoarthritis of the knee
• Ayurveda interventions for rheumatoid arthritis
• Azathioprine for treating rheumatoid arthritis
• Balance training (proprioceptive training) for patients with rheumatoid arthritis
• Balneotherapy (or spa therapy) for rheumatoid arthritis
• Balneotherapy for osteoarthritis
• Baricitinib for rheumatoid arthritis
• Belimumab for systemic lupus erythematosus
• Biologic interventions for fatigue in rheumatoid arthritis
• Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA)
• Biologics for rheumatoid arthritis: an overview of Cochrane reviews
• Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis
• Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis
• Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis
• Bisphosphonate therapy for children and adolescents with secondary osteoporosis
• Bisphosphonates for osteoarthritis
• Bisphosphonates for Paget's disease of bone in adults
• Bisphosphonates for postmenopausal osteoporosis: a network meta-analysis
• Bisphosphonates for steroid-induced osteoporosis
• Boswellia for osteoarthritis
• Botulinum toxin for shoulder pain
• Botulinum toxin injection for tennis elbow
• Braces and orthoses for treating osteoarthritis of the knee
• Calcitonin for preventing and treating corticosteroid-induced osteoporosis
• Calcium and vitamin D for corticosteroid-induced osteoporosis
• Calcium and vitamin D for increasing bone mineral density in premenopausal women
• Calcium channel blockers for primary and secondary Raynaud's phenomenon
• Calcium supplementation for improving bone mineral density in children
• Canadian C-spine rule and the National Emergency X-Radiography Utilization Study (NEXUS) for detecting clinically important cervical spine injury following blunt trauma
• Celecoxib for osteoarthritis
• Celecoxib for rheumatoid arthritis
• Cemented versus cementless surgical approach for total hip arthroplasty revision
• Cemented, cementless or hybrid fixation options in total knee arthroplasty for osteoarthritis and other non-traumatic diseases
• Certolizumab pegol (CDP870) for rheumatoid arthritis in adults
• Chinese herbal medicines for treating osteoporosis
• Chloroquines for the treatment of osteoarthritis
• Chondroitin for osteoarthritis
• Colchicine for acute gout
• Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
• Community-based exercise and physical activity for chronic low back pain
• Community-based exercise and physical activity programmes led by exercise professionals for osteoarthritis
• Comprehensive physiotherapy for rheumatoid arthritis
• Computer assisted knee arthroplasty for osteoarthritis and other non-traumatic diseases
• Continuous passive motion following total knee arthroplasty in people with arthritis
• Corticosteroid injection for de Quervain's tenosynovitis
• Corticosteroid injection for trigger finger in adults
• Corticosteroid injections for shoulder pain
• Corticosteroids for septic arthritis in children
• COVID-19 vaccination for people with autoimmune inflammatory rheumatic diseases on immunomodulatory therapies
• Cryotherapy following total knee replacement
• Curcuma longa (turmeric) or its active ingredients for osteoarthritis
• Custom-made foot orthoses for the treatment of foot pain
• Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis
• Cyclophosphamide for treating rheumatoid arthritis
• Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus
• Cyclosporine for treating rheumatoid arthritis
• Deep transverse friction massage for treating lateral elbow or lateral knee tendinitis
• Dehydroepiandrosterone for systemic lupus erythematosus
• Denosumab for preventing fractures in postmenopausal women with osteoporosis
• Diacerein for osteoarthritis
• Dietary interventions for rheumatoid arthritis
• Dietary supplements for chronic gout
• Disease modifying immunosuppressant drugs for juvenile-onset systemic lupus erythematosus
• Disease-modifying anti-rheumatic drugs (DMARDs) for Sjogren’s syndrome
• Disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a systematic review and network meta-analysis
• Dose reduction and discontinuation of biologic and targeted synthetic disease-modifying anti-rheumatic drugs (DMARDs) in people with axial spondyloarthritis and low disease activity
• Dose reduction and discontinuation of disease-modifying anti-rheumatic drugs (DMARDs) for juvenile idiopathic arthritis
• Down-titration and discontinuation strategies of tumour necrosis factor–blocking agents for rheumatoid arthritis in patients with low disease activity
• Doxycycline for osteoarthritis of the knee or hip
• Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol
• Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis
• Effects of different bearing surface materials on aseptic loosening of total hip arthroplasty in patients with osteoarthritis and other non-traumatic diseases of the hip.
• Effects of glucocorticoids on radiological progression in rheumatoid arthritis
• Electrical stimulation for the treatment of rheumatoid arthritis
• Electromagnetic fields for treating osteoarthritis
• Electrotherapy modalities for adhesive capsulitis (frozen shoulder)
• Electrotherapy modalities for lateral elbow pain
• Electrotherapy modalities for rotator cuff disease
• Erythropoiesis-stimulating agents for anemia in rheumatoid arthritis
• Etanercept for the treatment of rheumatoid arthritis
• Etidronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
• Exercise and physical therapy for systemic sclerosis
• Exercise as adjunctive therapy for systemic lupus erythematosus
• Exercise for acutely hospitalised older medical patients
• Exercise for hand osteoarthritis
• Exercise for improving outcomes after osteoporotic vertebral fracture
• Exercise for multidirectional instability of the shoulder
• Exercise for osteoarthritis of the hip
• Exercise for patellar tendinopathy
• Exercise for positive mental health outcomes in adults
• Exercise for preventing and treating osteoporosis in postmenopausal women
• Exercise for preventing low bone mass in young males and females
• Exercise for rheumatoid arthritis of the hand
• Exercise for treating fibromyalgia syndrome
• Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review
• Exercise programmes for ankylosing spondylitis
• Exercise therapy following surgical rotator cuff repair
• Exercise therapy in juvenile idiopathic arthritis
• Febuxostat for treating chronic gout
• Flexibility exercise training for adults with fibromyalgia
• Fluoride for treating postmenopausal osteoporosis
• Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis
• Food-based calcium or vitamin D or both for osteoporosis in postmenopausal women
• Foot orthoses for treating paediatric flat feet
• General strengthening exercise for chronic low back pain
• Glucocorticoid facet joint injection for chronic back or neck pain
• Glucocorticoid injections for lateral elbow pain
• Glucosamine therapy for treating osteoarthritis
• Golimumab for rheumatoid arthritis
• Herbal medicines for systemic lupus erythematosus
• Herbal therapy for treating rheumatoid arthritis
• High-intensity versus low-intensity physical activity or exercise in people with hip or knee osteoarthritis
• Hip resurfacing versus traditional total hip arthroplasty for osteoarthritis and other non-traumatic diseases of the hip
• Home versus center based physical activity programs in older adults
• Home-based exercise therapy for rheumatoid arthritis
• Homeopathy for osteoarthritis
• Hormone replacement therapy for osteoarthritis in peri-menopausal and post-menopausal women
• Human parathyroid hormone for preventing and treating glucocorticoid-induced osteoporosis
• Human parathyroid hormone for the treatment of osteoporosis in post-menopausal women
• Hyaluronate for shoulder osteoarthritis
• Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
• Hydroxychloroquine for systemic lupus erythematosus in adults
• Hypolipidemic and antihypertensive drugs for prevention of cardiovascular complications in patients with rheumatoid arthritis
• Iloprost and cisaprost for Raynaud's phenomenon in progressive systemic sclerosis
• Image-guided glucocorticoid injection versus injection without image guidance for shoulder pain
• Infliximab for the treatment of rheumatoid arthritis
• Injectable gold for rheumatoid arthritis
• Interleukin inhibitors for psoriatic arthritis
• Interleukin-1 inhibitors for acute gout
• Interventions for ganglion cysts in adults
• Interventions for lateral hip pain (tendinopathy or bursitis)
• Interventions for maintenance therapy for granulomatosis with polyangiitis and microscopic polyangiitis
• Interventions for pes planus
• Interventions for tophi in gout
• Interventions for treating psoriatic arthritis
• Interventions to improve adherence to exercise for chronic musculoskeletal pain in adults
• Intra-articular corticosteroid for knee osteoarthritis
• Intra-articular steroids and splints/rest for children with juvenile idiopathic arthritis and adults with rheumatoid arthritis
• Intravenous immunoglobulin for juvenile idiopathic arthritis
• Intravenous zoledronate for postmenopausal osteoporosis
• Isokinetic exercise for improving knee flexor and extensor muscles
• Joint lavage for osteoarthritis of the knee
• Ketanserin for Raynaud's phenomenon in progressive systemic sclerosis
• Kinesio taping for rotator cuff disease
• Leeches (Hirudinea) for osteoarthritis
• Leflunomide for the treatment of rheumatoid arthritis
• Lifestyle interventions for acute gout
• Lifestyle interventions for chronic gout
• Long-term glucocorticoids for rheumatoid arthritis
• Low level laser therapy (Classes I, II and III) for treating rheumatoid arthritis
• Manual therapy and exercise for adhesive capsulitis (frozen shoulder)
• Manual therapy and exercise for lateral elbow pain
• Manual therapy and exercise for rotator cuff disease
• Marine oil supplements for rheumatoid arthritis
• Metal versus non-metal backing of the tibial component for total knee replacement for osteoarthritis and/or rheumatoid arthritis.
• Methotrexate for ankylosing spondylitis
• Methotrexate for giant cell arteritis
• Methotrexate for juvenile idiopathic arthritis
• Methotrexate for polymyalgia rheumatica
• Methotrexate for psoriatic arthritis
• Methotrexate for treating rheumatoid arthritis
• Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis
• Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis
• Mind and body therapy for fibromyalgia
• Minimally invasive surgical approaches for total hip arthroplasty in adults with osteoarthritis
• Mixed exercise training for adults with fibromyalgia
• Mobile bearing vs fixed bearing prostheses for posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients with osteoarthritis and rheumatoid arthritis
• Mobility training for increasing mobility and functioning in older people with frailty
• Moderate-term, low-dose corticosteroids for rheumatoid arthritis
• Multidisciplinary rehabilitation for fibromyalgia and musculoskeletal pain in working age adults
• Multidisciplinary rehabilitation programmes following joint replacement at the hip and knee in chronic arthropathy
• Muscle relaxants for pain management in rheumatoid arthritis
• Neuromodulators for pain management in rheumatoid arthritis
• Non-biologic pharmaceutical interventions for fatigue in rheumatoid arthritis
• Non-pharmacological interventions for fatigue in rheumatoid arthritis
• Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis)
• Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults
• Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger
• Non-steroidal anti-inflammatory drugs for acute gout
• Non-surgical treatment for lower limb apophyseal injuries
• NSAIDs, analgesics and opioids agents for fibromyalgia syndrome
• Occupational therapy for rheumatoid arthritis
• Ofatumumab for rheumatoid arthritis
• Operative and non-operative treatment options for dislocation of the hip following total hip arthroplasty
• Opioid therapy for treating rheumatoid arthritis pain
• Oral herbal therapies for treating osteoarthritis
• Oral or transdermal opioids for osteoarthritis of the knee or hip
• Oral steroids for adhesive capsulitis
• Orthotic devices for the treatment of tennis elbow
• Osteotomy for treating knee osteoarthritis
• Pain management for inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and other spondyloarthritis) and gastrointestinal or liver comorbidity
• Pain management for rheumatoid arthritis and cardiovascular or renal comorbidity
• Paracetamol versus nonsteroidal anti-inflammatory drugs for rheumatoid arthritis
• Paracetamol versus placebo for knee and hip osteoarthritis
• Patient education for adults with rheumatoid arthritis
• Patient-specific cutting guides for total knee arthroplasty
• Pegloticase for chronic gout
• Penicillamine for treating rheumatoid arthritis
• Percutaneous vertebroplasty for osteoporotic vertebral compression fracture
• Periarticular analgesia for postoperative pain following total hip replacement
• Periarticular analgesia for postoperative pain following total knee replacement
• Perioperative interventions for smoking cessation in hip and knee arthroplasty for osteoarthritis and other non-traumatic diseases
• Perioperative use of disease modifying anti-rheumatic drugs (DMARDs) in people with inflammatory arthritis
• Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
• Pharmacological interventions for preventing bone density loss in critically ill people
• Pharmacological therapies for the prevention of fractures in men
• Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews
• Pharmacotherapy for Behcet's syndrome
• Phosphodiesterase 4 inhibitors for psoriatic arthritis
• Physical activity for preventing or managing osteoporosis in men
• Physiotherapy and physiotherapeutical modalities for lateral epicondylitis
• Physiotherapy interventions for ankylosing spondylitis
• Physiotherapy interventions for shoulder pain
• Phytoestrogens in the treatment of postmenopausal osteoporosis
• Post-acute physiotherapy for primary total hip arthroplasty
• Post-acute physiotherapy for primary total knee arthroplasty
• Post-operative therapy for metacarpophalangeal arthroplasty
• Posterior versus lateral surgical approach for total hip arthroplasty in adults with osteoarthritis
• Prazosin for Raynaud's phenomenon in progressive systemic sclerosis
• Preoperative education for hip or knee replacement
• Processed versus fresh frozen bone for impaction bone grafting in revision hip arthroplasty
• Psychological therapies for improving outcomes after total hip or knee replacement in people with osteoarthritis and rheumatoid arthritis
• Rehabilitation after surgery for Dupuytren's Contracture
• Remote, face-to-face, and group-based interventions for promoting strength training in healthy community-based adults
• Resistance exercise training for fibromyalgia
• Retention versus sacrifice of the posterior cruciate ligament in total knee arthroplasty for treating osteoarthritis
• Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
• Rituximab for rheumatoid arthritis
• Rofecoxib for osteoarthritis
• Rofecoxib for rheumatoid arthritis
• S-Adenosylmethionine for osteoarthritis of the knee or hip
• Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
• Selective estrogen receptor modulators for preventing and treating postmenopausal osteoporosis
• Selective serotonin reuptake inhibitors for fibromyalgia syndrome
• Self management programme for ankylosing spondylitis
• Self-management education programmes for osteoarthritis
• Self-management education programmes for rheumatoid arthritis
• Shock wave therapy for lateral elbow pain
• Shock wave therapy for rotator cuff disease with or without calcification
• Shockwave therapy for plantar heel pain (plantar fasciitis)
• Shoe and heel lifts for leg length inequality in adults with musculoskeletal conditions
• Short-term glucocorticoids for flares in people with rheumatoid arthritis receiving disease-modifying anti-rheumatic drugs (DMARDs)
• Short-term induction glucocorticoids and disease-modifying anti-rheumatic drugs (DMARD) therapy for rheumatoid arthritis
• Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis
• Shoulder replacement surgery for osteoarthritis and rotator cuff tear arthropathy
• Splints and Orthosis for treating rheumatoid arthritis
• Statins for osteoporosis in postmenopausal women
• Stem cell transplantation for systemic sclerosis
• Stretch for the treatment and prevention of contractures
• Strontium ranelate for osteoarthritis
• Strontium ranelate for preventing and treating postmenopausal osteoporosis
• Subacromial decompression surgery for rotator cuff disease
• Subcutaneous or intramuscular methotrexate for rheumatoid arthritis
• Sulfasalazine for ankylosing spondylitis
• Sulfasalazine for treating rheumatoid arthritis
• Surface neuromuscular electrical stimulation for quadriceps strengthening pre and post total knee replacement
• Surgery for Dupuytren's contracture of the fingers
• Surgery for lateral elbow pain
• Surgery for patellar tendinopathy (jumper’s knee)
• Surgery for rotator cuff tears
• Surgery for shoulder osteoarthritis
• Surgery for treating hip impingement (femoroacetabular impingement)
• Surgery for trigger finger
• Surgical approaches in total knee arthroplasty
• Surgical interventions for failed primary knee replacement
• Surgical interventions for symptomatic mild to moderate knee osteoarthritis
• Surgical interventions for the rheumatoid shoulder
• Surgical interventions for treating hallux valgus and bunions
• Surgical management of Perthes disease
• Surgical treatment for advanced stage of avascular necrosis of the femoral head in adults
• Systemic corticosteroids for acute gout
• Tai Chi for rheumatoid arthritis
• Taping for knee osteoarthritis
• Telerehabilitation for hip or knee osteoarthritis
• Telerehabilitation versus conventional face-to-face land-based exercises following hip or knee arthroplasty
• The McKenzie method for (sub)acute non-specific low back pain
• Therapeutic ultrasound for osteoarthritis of the knee or hip
• Therapeutic ultrasound for the treatment of rheumatoid arthritis
• Thermotherapy for treating rheumatoid arthritis
• Thermotherapy for treatment of osteoarthritis
• TNF-alpha inhibitors for ankylosing spondylitis
• TNF-alpha inhibitors for psoriatic arthritis
• Tocilizumab for rheumatoid arthritis
• Topical glyceryl trinitrate for lateral elbow pain
• Topical glyceryl trinitrate for rotator cuff disease
• Topical herbal therapies for treating osteoarthritis
• Total and partial knee arthroplasty versus non-surgical interventions of the knee for moderate to severe osteoarthritis
• Total hip replacement surgery versus conservative care for hip osteoarthritis and other non-traumatic diseases
• Total joint replacement surgery versus conservative care for knee osteoarthritis and other non-traumatic diseases
• Tourniquet use for knee replacement surgery
• Traction for hip osteoarthritis
• Tramadol for osteoarthritis
• Transcutaneous electrical nerve stimulation (TENS) for the treatment of rheumatoid arthritis in the hand
• Transcutaneous electrostimulation for osteoarthritis of the knee
• Unicompartmental arthroplasty for knee osteoarthritis
• Uricosuric medications for chronic gout
• Viscosupplementation for the treatment of osteoarthritis of the knee
• Vitamin D supplementation for improving bone mineral density in children
• Vitamin D supplementation in infancy for improving bone density
• Vitamin D with or without calcium for treating osteoporosis in postmenopausal women
• Vitamin K for the prevention and treatment of osteoporosis in post-menopausal women
• Weight loss for overweight patients with knee or hip osteoarthritis
• Whole body vibration exercise training for fibromyalgia
• Whole body vibration for preventing and treating osteoporosis
• Yoga for osteoarthritis of the hip or knee
• Amitriptyline for fibromyalgia in adults
• Amitriptyline for neuropathic pain in adults
• Anti-depressants and centrally active agents for fibromyalgia syndrome
• Cognitive behavioural therapies for fibromyalgia syndrome
• Combinations of drugs versus single drugs to treat fibromyalgia pain in adults
• Does alendronate help prevent fractures caused by osteoporosis in postmenopausal women?
• Is exercise an effective therapy to treat knee osteoarthritis?
• Serotonin and noradrenaline reuptake inhibitors for fibromyalgia
• What are the benefits and harms of TNF inhibitors for people with psoriatic arthritis?
• What are the benefits and risks of alternative models of delivering care for people with low back pain?
• What are the benefits and risks of stem cell injections for knee osteoarthritis?New
• What are the benefits and risks of tumor necrosis factor inhibitors for juvenile idiopathic arthritis?
• What are the most effective treatments for arthritis of the big toe, excluding surgery?

• Health conditions older adults (0)
  • Dietary interventions (0)
  • Patient education and self-management (0)
  • Physical activity and exercise (0)
  • Prevention (0)
  • Psychological and behavioural interventions (0)
• Lupus Erythematosus [systemic, discoid, cutaneous, lupus nephritis] (8)
  • Prevention (0)
  • Therapeutic management (efficacy, effectiveness, safety) (7)
    • Antimalarials (hydroxychloroquine, chloroquine phosphate) (1)
      • Hydroxychloroquine for systemic lupus erythematosus in adults
    • Biologicals (BCell Toleragens) (2)
      • Disease modifying immunosuppressant drugs for juvenile-onset systemic lupus erythematosus
      • Belimumab for systemic lupus erythematosus
    • Corticosteroids (prednisone, solumedrol) (0)
    • Herbal (1)
      • Herbal medicines for systemic lupus erythematosus
    • Hormone replacement (1)
      • Dehydroepiandrosterone for systemic lupus erythematosus
    • Immunosuppressants (methotrexate, azathioprine, cyclophosphamide (2)
      • Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus
      • Disease modifying immunosuppressant drugs for juvenile-onset systemic lupus erythematosus
    • Treatment of lupus nephritis (0)
  • Non-medicinal interventions (1)
    • Exercise (1)
      • Exercise as adjunctive therapy for systemic lupus erythematosus
    • Patient counseling (0)
    • Patient education (0)
    • Psychological interventions (0)
    • Social support (0)
  • Diagnostic and prognostic testing (0)
    • Antinuclear antibodies (0)
    • Biopsy material (lung, heart, gut, kidney) (0)
    • Complement testing (0)
    • Genetic markers (0)
    • Lymphocyte markers (0)
  • Rehabilitation (0)
    • Exercise (0)
    • Patient education (0)
  • Alternative therapies (0)
• Gout [uric acid, hyperuricemia, pseudogout] (21)
  • Prevention (0)
    • Diet (0)
    • Education (0)
  • Treatment: chronic (13)
    • Allopurinol (1)
      • Allopurinol for chronic gout
    • Benzbromarone (1)
      • Uricosuric medications for chronic gout
    • Biologic (2)
      • Interleukin-1 inhibitors for acute gout
      • Pegloticase for chronic gout
    • Diet (2)
      • Lifestyle interventions for chronic gout
      • Lifestyle interventions for acute gout
    • Dietary supplements (1)
      • Dietary supplements for chronic gout
    • Febuxostat (1)
      • Febuxostat for treating chronic gout
    • Probenecid (1)
      • Uricosuric medications for chronic gout
    • Smoking cessation (2)
      • Lifestyle interventions for chronic gout
      • Lifestyle interventions for acute gout
    • Weight loss (2)
      • Lifestyle interventions for chronic gout
      • Lifestyle interventions for acute gout
  • Treatment: acute (5)
    • Biologics (1)
      • Interleukin-1 inhibitors for acute gout
    • Colchicine (1)
      • Colchicine for acute gout
    • Non-drug therapies (0)
    • Non-steroidal anti-inflammatory drugs (NSAID) (1)
      • Non-steroidal anti-inflammatory drugs for acute gout
    • Steroids (2)
      • Adrenocorticotropic hormone for acute gout
      • Systemic corticosteroids for acute gout
  • Alternative therapies (0)
  • Rehabilitation (0)
    • Education (0)
  • Treatment: tophi gout (3)
    • Benzbromarone (1)
      • Interventions for tophi in gout
    • Probenecid (1)
      • Interventions for tophi in gout
    • Surgery (1)
      • Interventions for tophi in gout
• Osteoarthritis (116)
  • Adherence to treatment (1)
    • Interventions to improve adherence to exercise for chronic musculoskeletal pain in adults
  • Prevention (0)
  • Treatment [Pharmacological interventions] (29)
    • Analgesia (10)
      • Acetaminophen for osteoarthritis
      • Antidepressants for hip and knee osteoarthritis
      • Botulinum toxin for shoulder pain
      • Chloroquines for the treatment of osteoarthritis
      • Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
      • Oral or transdermal opioids for osteoarthritis of the knee or hip
      • Paracetamol versus placebo for knee and hip osteoarthritis
      • Periarticular analgesia for postoperative pain following total hip replacement
      • Periarticular analgesia for postoperative pain following total knee replacement
      • Tramadol for osteoarthritis
    • Antibiotics (1)
      • Doxycycline for osteoarthritis of the knee or hip
    • Bisphosphonates (1)
      • Bisphosphonates for osteoarthritis
    • Dietary supplements (3)
      • Chondroitin for osteoarthritis
      • Glucosamine therapy for treating osteoarthritis
      • S-Adenosylmethionine for osteoarthritis of the knee or hip
    • Intra-articular injections (6)
      • Autologous blood product injections including platelet-rich plasma for osteoarthritis of the knee
      • Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
      • Intra-articular corticosteroid for knee osteoarthritis
      • Viscosupplementation for the treatment of osteoarthritis of the knee
      • What are the benefits and risks of stem cell injections for knee osteoarthritis?New
      • What are the most effective treatments for arthritis of the big toe, excluding surgery?
    • Non-steroidal anti-inflammatory drugs (NSAID) (4)
      • Celecoxib for osteoarthritis
      • Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
      • Rofecoxib for osteoarthritis
      • What are the most effective treatments for arthritis of the big toe, excluding surgery?
    • Hormone Replacement Therapy (1)
      • Hormone replacement therapy for osteoarthritis in peri-menopausal and post-menopausal women
    • Biologics (0)
    • Other pharmacological interventions (3)
      • Diacerein for osteoarthritis
      • Strontium ranelate for osteoarthritis
      • Weight loss for overweight patients with knee or hip osteoarthritis
  • Treatment [Non-pharmocological interventions] (50)
    • Alternative therapies [i.e.acupuncture] (10)
      • Acupuncture for hip osteoarthritis
      • Acupuncture for peripheral joint osteoarthritis
      • Curcuma longa (turmeric) or its active ingredients for osteoarthritis
      • Homeopathy for osteoarthritis
      • Leeches (Hirudinea) for osteoarthritis
      • Oral herbal therapies for treating osteoarthritis
      • Perioperative interventions for smoking cessation in hip and knee arthroplasty for osteoarthritis and other non-traumatic diseases
      • Topical herbal therapies for treating osteoarthritis
      • Weight loss for overweight patients with knee or hip osteoarthritis
      • Yoga for osteoarthritis of the hip or knee
    • Balneotherapy (1)
      • Balneotherapy for osteoarthritis
    • Laser therapy (1)
      • What are the most effective treatments for arthritis of the big toe, excluding surgery?
    • Psychological interventions (1)
      • Telerehabilitation for hip or knee osteoarthritis
    • Surgery (32)
      • Surgical interventions for treating hallux valgus and bunions
      • Arthroscopic debridement for knee osteoarthritis
      • Arthroscopic surgery for degenerative knee disease (osteoarthritis including degenerative meniscal tears)
      • Cemented versus cementless surgical approach for total hip arthroplasty revision
      • Cryotherapy following total knee replacement
      • Computer assisted knee arthroplasty for osteoarthritis and other non-traumatic diseases
      • Effects of different bearing surface materials on aseptic loosening of total hip arthroplasty in patients with osteoarthritis and other non-traumatic diseases of the hip.
      • Cemented, cementless or hybrid fixation options in total knee arthroplasty for osteoarthritis and other non-traumatic diseases
      • Hip resurfacing versus traditional total hip arthroplasty for osteoarthritis and other non-traumatic diseases of the hip
      • Mobile bearing vs fixed bearing prostheses for posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients with osteoarthritis and rheumatoid arthritis
      • Joint lavage for osteoarthritis of the knee
      • Metal versus non-metal backing of the tibial component for total knee replacement for osteoarthritis and/or rheumatoid arthritis.
      • Minimally invasive surgical approaches for total hip arthroplasty in adults with osteoarthritis
      • Osteotomy for treating knee osteoarthritis
      • Patient-specific cutting guides for total knee arthroplasty
      • Periarticular analgesia for postoperative pain following total hip replacement
      • Periarticular analgesia for postoperative pain following total knee replacement
      • Processed versus fresh frozen bone for impaction bone grafting in revision hip arthroplasty
      • Psychological therapies for improving outcomes after total hip or knee replacement in people with osteoarthritis and rheumatoid arthritis
      • Retention versus sacrifice of the posterior cruciate ligament in total knee arthroplasty for treating osteoarthritis
      • Shoulder replacement surgery for osteoarthritis and rotator cuff tear arthropathy
      • Surgery for shoulder osteoarthritis
      • Surgical approaches in total knee arthroplasty
      • Surgical interventions for failed primary knee replacement
      • Surgical interventions for symptomatic mild to moderate knee osteoarthritis
      • Posterior versus lateral surgical approach for total hip arthroplasty in adults with osteoarthritis
      • Total hip replacement surgery versus conservative care for hip osteoarthritis and other non-traumatic diseases
      • Total joint replacement surgery versus conservative care for knee osteoarthritis and other non-traumatic diseases
      • Operative and non-operative treatment options for dislocation of the hip following total hip arthroplasty
      • Unicompartmental arthroplasty for knee osteoarthritis
      • Tourniquet use for knee replacement surgery
      • What are the most effective treatments for arthritis of the big toe, excluding surgery?
    • TENS (2)
      • Transcutaneous electrostimulation for osteoarthritis of the knee
      • What are the most effective treatments for arthritis of the big toe, excluding surgery?
    • Therapeutic Ultrasound (2)
      • Therapeutic ultrasound for osteoarthritis of the knee or hip
      • What are the most effective treatments for arthritis of the big toe, excluding surgery?
    • Thermotherapy (heat or cold) (1)
      • Thermotherapy for treatment of osteoarthritis
  • Rehabilitation (36)
    • Exercise (12)
      • Exercise therapy for osteoarthritis (12)
        • Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee
        • Aquatic exercise for the treatment of knee and hip osteoarthritis
        • High-intensity versus low-intensity physical activity or exercise in people with hip or knee osteoarthritis
        • Community-based exercise and physical activity programmes led by exercise professionals for osteoarthritis
        • Exercise for hand osteoarthritis
        • Exercise for osteoarthritis of the hip
        • Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
        • Is exercise an effective therapy to treat knee osteoarthritis?
        • Home versus center based physical activity programs in older adults
        • Telerehabilitation for hip or knee osteoarthritis
        • Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review
        • What are the most effective treatments for arthritis of the big toe, excluding surgery?
    • Occupational therapy (1)
      • Assistive devices, hip precautions, environmental modifications and training to prevent dislocation and improve function after hip arthroplasty
    • Patient education (4)
      • Perioperative interventions for smoking cessation in hip and knee arthroplasty for osteoarthritis and other non-traumatic diseases
      • Preoperative education for hip or knee replacement
      • Self-management education programmes for osteoarthritis
      • Telerehabilitation for hip or knee osteoarthritis
    • Continuous Passive Motion (1)
      • Continuous passive motion following total knee arthroplasty in people with arthritis
    • Modalities (5)
      • Surface neuromuscular electrical stimulation for quadriceps strengthening pre and post total knee replacement
      • Electromagnetic fields for treating osteoarthritis
      • Isokinetic exercise for improving knee flexor and extensor muscles
      • Traction for hip osteoarthritis
      • What are the most effective treatments for arthritis of the big toe, excluding surgery?
    • Physiotherapy (4)
      • Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
      • Post-acute physiotherapy for primary total hip arthroplasty
      • Post-acute physiotherapy for primary total knee arthroplasty
      • Taping for knee osteoarthritis
    • Splints/Orthoses (5)
      • Braces and orthoses for treating osteoarthritis of the knee
      • Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
      • Shoe and heel lifts for leg length inequality in adults with musculoskeletal conditions
      • Taping for knee osteoarthritis
      • What are the most effective treatments for arthritis of the big toe, excluding surgery?
    • Multidisciplinary rehabilitation (1)
      • Multidisciplinary rehabilitation programmes following joint replacement at the hip and knee in chronic arthropathy
    • Tai Chi (2)
      • Exercise for osteoarthritis of the hip
      • Is exercise an effective therapy to treat knee osteoarthritis?
    • Telerehabilitation (1)
      • Telerehabilitation versus conventional face-to-face land-based exercises following hip or knee arthroplasty
• Osteoporosis [premenopausal, post-menopausal, corticosteroid induced, osteoporosis in men ] (50)
  • Prevention (10)
    • Diet (6)
      • Calcium and vitamin D for increasing bone mineral density in premenopausal women
      • Food-based calcium or vitamin D or both for osteoporosis in postmenopausal women
      • Pharmacological interventions for preventing bone density loss in critically ill people
      • Phytoestrogens in the treatment of postmenopausal osteoporosis
      • Vitamin D supplementation for improving bone mineral density in children
      • Vitamin D supplementation in infancy for improving bone density
    • Education (0)
    • Exercise (4)
      • Exercise for preventing and treating osteoporosis in postmenopausal women
      • Exercise for preventing low bone mass in young males and females
      • Physical activity for preventing or managing osteoporosis in men
      • Whole body vibration for preventing and treating osteoporosis
  • Treatment [non-pharmacological] (6)
    • Herbal (1)
      • Chinese herbal medicines for treating osteoporosis
    • Rehabilitation (4)
      • Exercise (3)
        • Exercise for improving outcomes after osteoporotic vertebral fracture
        • Exercise for preventing and treating osteoporosis in postmenopausal women
        • Whole body vibration for preventing and treating osteoporosis
      • Modalities (0)
      • Patient education (1)
        • Preoperative education for hip or knee replacement
    • Surgery (1)
      • Percutaneous vertebroplasty for osteoporotic vertebral compression fracture
  • Treatment [pharmacological agents] (34)
    • Anti-sclerostin antibodies (1)
      • Anti-sclerostin antibodies for the treatment of osteoporosis
    • Bisphosphonates (9)
      • Bisphosphonates (5)
        • Bisphosphonate therapy for children and adolescents with secondary osteoporosis
        • Bisphosphonates for steroid-induced osteoporosis
        • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
        • Pharmacological interventions for preventing bone density loss in critically ill people
        • Pharmacological therapies for the prevention of fractures in men
      • Alendronate (1)
        • Does alendronate help prevent fractures caused by osteoporosis in postmenopausal women?
      • Clodronate (0)
      • Etidronate (1)
        • Etidronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
      • Ibandronate (0)
      • Risedronate (1)
        • Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
      • Zolendronate (1)
        • Intravenous zoledronate for postmenopausal osteoporosis
    • Denosumab (2)
      • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
      • Pharmacological therapies for the prevention of fractures in men
    • Pamidronate (1)
      • Zolendronate (1)
        • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
    • Calcium (2)
      • Calcium supplementation for improving bone mineral density in children
      • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
    • Calcium and Vitamin D in combination (2)
      • Calcium and vitamin D for corticosteroid-induced osteoporosis
      • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
    • Calcitonin (2)
      • Calcitonin for preventing and treating corticosteroid-induced osteoporosis
      • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
    • Fluoride (1)
      • Fluoride for treating postmenopausal osteoporosis
    • Growth hormone (0)
    • Hormone replacement therapy (0)
    • Selective estrogen receptor modulators (SERMS) (6)
      • Bazedoxifene (1)
        • Selective estrogen receptor modulators for preventing and treating postmenopausal osteoporosis
      • Lasofoxifene (1)
        • Selective estrogen receptor modulators for preventing and treating postmenopausal osteoporosis
      • Nandrolone decanoate (1)
        • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
      • Raloxifene (2)
        • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
        • Selective estrogen receptor modulators for preventing and treating postmenopausal osteoporosis
      • Tibolone (1)
        • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
    • Ipriflavone (0)
    • Parathyroid hormone (4)
      • Human parathyroid hormone for preventing and treating glucocorticoid-induced osteoporosis
      • Human parathyroid hormone for the treatment of osteoporosis in post-menopausal women
      • Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty
      • Pharmacological therapies for the prevention of fractures in men
    • Statins (1)
      • Statins for osteoporosis in postmenopausal women
    • Vitamin D (1)
      • Vitamin D with or without calcium for treating osteoporosis in postmenopausal women
    • Calcitriol (0)
    • Cholecalciferol (0)
    • Alternative therapies (0)
    • Strontium ralenate (1)
      • Strontium ranelate for preventing and treating postmenopausal osteoporosis
    • Vitamin K (1)
      • Vitamin K for the prevention and treatment of osteoporosis in post-menopausal women
• Other reviews (3)
  • Canadian C-spine rule and the National Emergency X-Radiography Utilization Study (NEXUS) for detecting clinically important cervical spine injury following blunt trauma
  • COVID-19 vaccination for people with autoimmune inflammatory rheumatic diseases on immunomodulatory therapies
  • What are the benefits and risks of alternative models of delivering care for people with low back pain?
• Pediatric Rheumatology [juvenile rheumatoid] (8)
  • Pharmacological interventions (6)
    • Biologics (2)
      • Dose reduction and discontinuation of disease-modifying anti-rheumatic drugs (DMARDs) for juvenile idiopathic arthritis
      • What are the benefits and risks of tumor necrosis factor inhibitors for juvenile idiopathic arthritis?
    • Methotrexate (2)
      • Dose reduction and discontinuation of disease-modifying anti-rheumatic drugs (DMARDs) for juvenile idiopathic arthritis
      • Methotrexate for juvenile idiopathic arthritis
    • Other Pharmacological interventions (2)
      • Corticosteroids for septic arthritis in children
      • Intravenous immunoglobulin for juvenile idiopathic arthritis
  • Rehabilitation (2)
    • Exercise (1)
      • Exercise therapy in juvenile idiopathic arthritis
    • Patient education (0)
    • Splints/Rest (1)
      • Intra-articular steroids and splints/rest for children with juvenile idiopathic arthritis and adults with rheumatoid arthritis
  • Alternative therapies (0)
• Legg Perthes (1)
  • Surgical management (1)
    • Surgical management of Perthes disease
• Paget's Disease (1)
  • Bisphosphonates for Paget's disease of bone in adults
• Physical activity (4)
  • Exercise (3)
    • Exercise for acutely hospitalised older medical patients
    • Exercise therapy following surgical rotator cuff repair
    • Mobility training for increasing mobility and functioning in older people with frailty
  • Mental health (1)
    • Exercise for positive mental health outcomes in adults
• Reactive arthritis (2)
  • Treatment - Pharmacological (2)
    • Antibiotics for reactive arthritis
    • Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
• Rheumatoid Arthritis (87)
  • Prevention (1)
    • COVID19 (0)
    • Cardiovascular complications (1)
      • Hypolipidemic and antihypertensive drugs for prevention of cardiovascular complications in patients with rheumatoid arthritis
    • Diet (0)
    • Periodontal disease (0)
  • Nonpharmacologic (30)
    • Assistive Technology (1)
      • Assistive technology for rheumatoid arthritis
    • Diet (2)
      • Marine oil supplements for rheumatoid arthritis
      • Dietary interventions for rheumatoid arthritis
    • Exercise (3)
      • Balance training (proprioceptive training) for patients with rheumatoid arthritis
      • Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis
      • Home-based exercise therapy for rheumatoid arthritis
    • Nonpharmacologic (1)
      • Non-pharmacological interventions for fatigue in rheumatoid arthritis
    • Surgery (4)
      • Cemented, cementless or hybrid fixation options in total knee arthroplasty for osteoarthritis and other non-traumatic diseases
      • Hip resurfacing versus traditional total hip arthroplasty for osteoarthritis and other non-traumatic diseases of the hip
      • Mobile bearing vs fixed bearing prostheses for posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients with osteoarthritis and rheumatoid arthritis
      • Surgical interventions for the rheumatoid shoulder
    • Alternative therapies (i.e. acupuncture) (3)
      • Ayurveda interventions for rheumatoid arthritis
      • Herbal therapy for treating rheumatoid arthritis
      • Tai Chi for rheumatoid arthritis
    • Rehabilitation (16)
      • Occupational Therapy (2)
        • Occupational therapy for rheumatoid arthritis
        • Splints and Orthosis for treating rheumatoid arthritis
      • Physical Therapy (14)
        • Exercise (5)
          • Aquatic therapy exercise for treating rheumatoid arthritis
          • Comprehensive physiotherapy for rheumatoid arthritis
          • Cyclophosphamide for treating rheumatoid arthritis
          • Exercise for rheumatoid arthritis of the hand
          • Post-operative therapy for metacarpophalangeal arthroplasty
        • Thermotherapy (1)
          • Thermotherapy for treating rheumatoid arthritis
        • Balneotherapy (1)
          • Balneotherapy (or spa therapy) for rheumatoid arthritis
        • Electrotherapy (5)
          • Acupuncture and electroacupuncture for the treatment of rheumatoid arthritis
          • Therapeutic ultrasound for the treatment of rheumatoid arthritis
          • Low level laser therapy (Classes I, II and III) for treating rheumatoid arthritis
          • Electrical stimulation for the treatment of rheumatoid arthritis
          • Transcutaneous electrical nerve stimulation (TENS) for the treatment of rheumatoid arthritis in the hand
        • Education (2)
          • Patient education for adults with rheumatoid arthritis
          • Self-management education programmes for rheumatoid arthritis
    • exercise (0)
  • Treatment [Pharmacological interventions] (56)
    • Biologics (18)
      • Abatacept for rheumatoid arthritis
      • Adalimumab for treating rheumatoid arthritis
      • Anakinra for rheumatoid arthritis
      • Baricitinib for rheumatoid arthritis
      • Biologic interventions for fatigue in rheumatoid arthritis
      • Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis
      • Biologics for rheumatoid arthritis: an overview of Cochrane reviews
      • Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA)
      • Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis
      • Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis
      • Certolizumab pegol (CDP870) for rheumatoid arthritis in adults
      • Golimumab for rheumatoid arthritis
      • Down-titration and discontinuation strategies of tumour necrosis factor–blocking agents for rheumatoid arthritis in patients with low disease activity
      • Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis
      • Ofatumumab for rheumatoid arthritis
      • Rituximab for rheumatoid arthritis
      • Adverse effects of biologics: a network meta-analysis and Cochrane overview
      • Tocilizumab for rheumatoid arthritis
    • Disease modifying antirheumatic drugs (DMARDs), also slow acting antirheumatic drugs; second line agents (SAARDs) (17)
      • Iguratimod (0)
      • Methotrexate (5)
        • Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis
        • Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis
        • Methotrexate for treating rheumatoid arthritis
        • Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
        • Subcutaneous or intramuscular methotrexate for rheumatoid arthritis
      • Gold, auranofin, myochrisine, solgonal (2)
        • Auranofin versus placebo in rheumatoid arthritis
        • Injectable gold for rheumatoid arthritis
      • Hydroxychloroquine (2)
        • Antimalarials for treating rheumatoid arthritis
        • Disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a systematic review and network meta-analysis
      • Chloroquine (1)
        • Antimalarials for treating rheumatoid arthritis
      • Azathioprine (1)
        • Azathioprine for treating rheumatoid arthritis
      • Cyclosphosphamide (1)
        • Cyclophosphamide for treating rheumatoid arthritis
      • Cyclosporine (1)
        • Cyclosporine for treating rheumatoid arthritis
      • Leflunomide (1)
        • Leflunomide for the treatment of rheumatoid arthritis
      • Nitrogen Mustard (0)
      • Mycophenolic acid (0)
      • Sulfasalazine (1)
        • Sulfasalazine for treating rheumatoid arthritis
      • Antimicrobial (0)
      • Eythropoietin (1)
        • Erythropoiesis-stimulating agents for anemia in rheumatoid arthritis
      • Penicillamine (1)
        • Penicillamine for treating rheumatoid arthritis
    • Intra-articular injections (0)
    • Non-biologics (1)
      • Non-biologic pharmaceutical interventions for fatigue in rheumatoid arthritis
    • Steroids (4)
      • Effects of glucocorticoids on radiological progression in rheumatoid arthritis
      • Long-term glucocorticoids for rheumatoid arthritis
      • Short-term glucocorticoids for flares in people with rheumatoid arthritis receiving disease-modifying anti-rheumatic drugs (DMARDs)
      • Short-term induction glucocorticoids and disease-modifying anti-rheumatic drugs (DMARD) therapy for rheumatoid arthritis
    • Symptom modifying anti-rheumatic drugs (SMARDs) (16)
      • Non-steroidal anti-inflammatory drugs (NSAIDs) (2)
        • Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
        • Paracetamol versus nonsteroidal anti-inflammatory drugs for rheumatoid arthritis
      • Selective Cox 2 inhibitors (NSAIDs) (3)
        • Celecoxib for rheumatoid arthritis
        • Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
        • Rofecoxib for rheumatoid arthritis
      • Analgesics (7)
        • Antidepressants for pain management in rheumatoid arthritis
        • Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
        • Muscle relaxants for pain management in rheumatoid arthritis
        • Neuromodulators for pain management in rheumatoid arthritis
        • Opioid therapy for treating rheumatoid arthritis pain
        • Pain management for inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and other spondyloarthritis) and gastrointestinal or liver comorbidity
        • Pain management for rheumatoid arthritis and cardiovascular or renal comorbidity
      • Corticosteroids (2)
        • Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis
        • Moderate-term, low-dose corticosteroids for rheumatoid arthritis
      • Fish Oil (0)
      • Radiation synovectomy (0)
        • Yttrium90 (0)
      • Biologics (2)
        • AntiCD4, Anti TNF (2)
          • Etanercept for the treatment of rheumatoid arthritis
          • Infliximab for the treatment of rheumatoid arthritis
        • Analgesics for chronic, not acute rheumatoid arthritis (0)
      • Bone marrow transplant (0)
        • Stem cell transplant (0)
      • Steroids (0)
    • Disease controlling antirheumatic therapy (DCARTs only) (0)
• Sjogren's syndrome (1)
  • Treatment (1)
    • Biologics (1)
      • Disease-modifying anti-rheumatic drugs (DMARDs) for Sjogren’s syndrome
    • Corticosteroids (0)
    • Non-pharmacological interventions (0)
• Soft tissue [rheumatism, rheumatic disease, bursitis, tendonitis] (78)
  • Prevention (1)
    • Kinesio taping for rotator cuff disease
  • Treatment of Fibromyalgia (14)
    • Acupuncture for treating fibromyalgia
    • Aerobic exercise training for adults with fibromyalgia
    • Amitriptyline for fibromyalgia in adults
    • Amitriptyline for neuropathic pain in adults
    • Aquatic exercise training for fibromyalgia
    • Cognitive behavioural therapies for fibromyalgia syndrome
    • Combinations of drugs versus single drugs to treat fibromyalgia pain in adults
    • Exercise for treating fibromyalgia syndrome
    • Flexibility exercise training for adults with fibromyalgia
    • Mixed exercise training for adults with fibromyalgia
    • Multidisciplinary rehabilitation for fibromyalgia and musculoskeletal pain in working age adults
    • NSAIDs, analgesics and opioids agents for fibromyalgia syndrome
    • Resistance exercise training for fibromyalgia
    • Whole body vibration exercise training for fibromyalgia
  • Pharmacologic (7)
    • Analgesics (0)
    • Centrally active anti-depressants (3)
      • Anti-depressants and centrally active agents for fibromyalgia syndrome
      • Selective serotonin reuptake inhibitors for fibromyalgia syndrome
      • Serotonin and noradrenaline reuptake inhibitors for fibromyalgia
    • Centrally active muscle relaxants (0)
    • Hypnotics (0)
    • Non-steroidal anti-inflammatory drugs [NSAID] (1)
      • Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger
    • Opiods (0)
    • Tender point injections (0)
    • Other (3)
      • Botulinum toxin for shoulder pain
      • Topical glyceryl trinitrate for rotator cuff disease
      • Topical glyceryl trinitrate for lateral elbow pain
  • Non-pharmacologic (4)
    • Surgery (3)
      • Surgery for treating hip impingement (femoroacetabular impingement)
      • Surgery for patellar tendinopathy (jumper’s knee)
      • Surgical treatment for advanced stage of avascular necrosis of the femoral head in adults
    • Exercise (1)
      • Stretch for the treatment and prevention of contractures
  • Psychological therapy (2)
    • EMG biofeedback (0)
    • Cognitive therapy (1)
      • Mind and body therapy for fibromyalgia
    • Relaxation therapy (1)
      • Mind and body therapy for fibromyalgia
    • Hypnosis (0)
  • Alternative therapies (2)
    • Acupuncture (1)
      • Acupuncture for treating fibromyalgia
    • Tai Chi (1)
      • Mind and body therapy for fibromyalgia
    • Yoga (0)
    • Chiropractic (0)
    • Nutraceuticals and vitamins (0)
    • Herbal therapies (0)
  • Treatment of shoulder pain (19)
    • Pharmacologic (4)
      • Analgesics (0)
      • Centrally active anti-depressants (0)
      • Centrally active muscle relaxants (0)
      • Hypnotics (0)
      • Non-steroidal anti-inflammatory drugs [NSAID] (0)
      • Opiods (0)
      • Tender point injections (3)
        • Corticosteroid injections for shoulder pain
        • Hyaluronate for shoulder osteoarthritis
        • Image-guided glucocorticoid injection versus injection without image guidance for shoulder pain
      • Other (1)
        • Oral steroids for adhesive capsulitis
    • Psychological therapy (0)
      • EMG biofeedback (0)
      • Cognitive therapy (0)
      • Relaxation therapy (0)
      • Hypnosis (0)
    • Non-pharmacologic (10)
      • Surgery (2)
        • Surgery for rotator cuff tears
        • Subacromial decompression surgery for rotator cuff disease
      • Rehabilitation (8)
        • Acupuncture for shoulder pain
        • Arthrographic distension for adhesive capsulitis (frozen shoulder)
        • Electrotherapy modalities for adhesive capsulitis (frozen shoulder)
        • Electrotherapy modalities for rotator cuff disease
        • Manual therapy and exercise for adhesive capsulitis (frozen shoulder)
        • Manual therapy and exercise for rotator cuff disease
        • Shock wave therapy for rotator cuff disease with or without calcification
        • Physiotherapy interventions for shoulder pain
    • Alternative therapies (5)
      • Acupuncture (5)
        • Electrotherapy modalities for adhesive capsulitis (frozen shoulder)
        • Electrotherapy modalities for rotator cuff disease
        • Manual therapy and exercise for adhesive capsulitis (frozen shoulder)
        • Manual therapy and exercise for rotator cuff disease
        • Physiotherapy interventions for shoulder pain
      • Tai Chi (0)
      • Yoga (0)
      • Chiropractic (0)
      • Nutraceuticals and vitamins (0)
      • Herbal therapies (0)
  • Treatment of elbow pain (12)
    • Pharmacologic (4)
      • Analgesics (0)
      • Centrally active anti-depressants (0)
      • Centrally active muscle relaxants (0)
      • Hypnotics (0)
      • Non-steroidal anti-inflammatory drugs [NSAID] (1)
        • Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults
      • Opioids (0)
      • Tender point injections (3)
        • Autologous blood and platelet-rich plasma injection therapy for lateral elbow pain
        • Botulinum toxin injection for tennis elbow
        • Glucocorticoid injections for lateral elbow pain
    • Non-pharmacologic (7)
      • Orthotics (1)
        • Orthotic devices for the treatment of tennis elbow
      • Physiotherapy (4)
        • Electrotherapy modalities for lateral elbow pain
        • Manual therapy and exercise for lateral elbow pain
        • Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults
        • Physiotherapy and physiotherapeutical modalities for lateral epicondylitis
      • Surgery (1)
        • Surgery for lateral elbow pain
      • Shock wave therapy (1)
        • Shock wave therapy for lateral elbow pain
    • Psychological therapy (0)
      • EMG biofeedback (0)
      • Cognitive therapy (0)
      • Relaxation therapy (0)
      • Hypnosis (0)
    • Alternative therapies (1)
      • Acupuncture (1)
        • Acupuncture for lateral elbow pain
      • Tai Chi (0)
      • Yoga (0)
      • Chiropractic (0)
      • Nutraceuticals and vitamins (0)
      • Herbal therapies (0)
      • Rehabilitation (0)
  • Treatment of knee pain (2)
    • Pharmacologic (0)
      • Analgesics (0)
      • Centrally active anti-depressants (0)
      • Centrally active muscle relaxants (0)
      • Hypnotics (0)
      • Non-steroidal anti-inflammatory drugs [NSAID] (0)
      • Opiods (0)
      • Tender point injections (0)
    • Psychological therapy (0)
      • EMG biofeedback (0)
      • Cognitive therapy (0)
      • Relaxation therapy (0)
      • Hypnosis (0)
    • Alternative therapies (1)
      • Acupuncture (0)
      • Tai Chi (0)
      • Yoga (0)
      • Chiropractic (0)
      • Nutraceuticals and vitamins (0)
      • Herbal therapies (0)
      • Rehabilitation (1)
        • Deep transverse friction massage for treating lateral elbow or lateral knee tendinitis
    • Surgery (1)
      • Surgery for patellar tendinopathy (jumper’s knee)
  • Treatment of ankle pain (0)
  • Pharmacologic (0)
    • Analgesics (0)
    • Centrally active anti-depressants (0)
    • Centrally active muscle relaxants (0)
    • Hypnotics (0)
    • Non-steroidal anti-inflammatory drugs [NSAID] (0)
    • Opiods (0)
    • Tender point injections (0)
  • Psychological therapy (1)
    • EMG biofeedback (0)
    • Cognitive therapy (0)
    • Relaxation therapy (1)
      • Mind and body therapy for fibromyalgia
    • Hypnosis (0)
  • Alternative therapies (0)
    • Acupuncture (0)
    • Tai Chi (0)
    • Yoga (0)
    • Chiropractic (0)
    • Nutraceuticals and vitamins (0)
    • Herbal therapies (0)
  • Treatment of foot pain (5)
    • Custom-made foot orthoses for the treatment of foot pain
    • Foot orthoses for treating paediatric flat feet
    • Interventions for pes planus
    • Shockwave therapy for plantar heel pain (plantar fasciitis)
    • Shoe and heel lifts for leg length inequality in adults with musculoskeletal conditions
  • Pharmacologic (0)
    • Analgesics (0)
    • Centrally active anti-depressants (0)
    • Centrally active muscle relaxants (0)
    • Hypnotics (0)
    • Non-steroidal anti-inflammatory drugs [NSAID] (0)
    • Opiods (0)
    • Tender point injections (0)
    • Interventions (0)
  • Psychological therapy (0)
    • EMG biofeedback (0)
    • Cognitive therapy (0)
    • Relaxation therapy (0)
    • Hypnosis (0)
  • Alternative therapies (0)
    • Acupuncture (0)
    • Tai Chi (0)
    • Yoga (0)
    • Chiropractic (0)
    • Nutraceuticals and vitamins (0)
    • Herbal therapies (0)
  • Treatment of hand pain (4)
    • Non-pharmacological (2)
      • Rehabilitation (0)
      • Surgery (2)
        • Surgery for Dupuytren's contracture of the fingers
        • Surgery for trigger finger
    • Pharmacological (2)
      • Corticosteroid injection for de Quervain's tenosynovitis
      • Corticosteroid injection for trigger finger in adults
  • Pharmacologic (0)
    • Analgesics (0)
    • Centrally active anti-depressants (0)
    • Centrally active muscle relaxants (0)
    • Hypnotics (0)
    • Non-steroidal anti-inflammatory drugs [NSAID] (0)
    • Opiods (0)
    • Tender point injections (0)
  • Psychological therapy (0)
    • EMG biofeedback (0)
    • Cognitive therapy (0)
    • Relaxation therapy (0)
    • Hypnosis (0)
  • Alternative therapies (0)
    • Acupuncture (0)
    • Tai Chi (0)
    • Yoga (0)
    • Chiropractic (0)
    • Nutraceuticals and vitamins (0)
    • Herbal therapies (0)
  • Treatment of hip pain (1)
    • Interventions for lateral hip pain (tendinopathy or bursitis)
  • Pharmacologic (0)
    • Analgesics (0)
    • Centrally active anti-depressants (0)
    • Centrally active muscle relaxants (0)
    • Hypnotics (0)
    • Non-steroidal anti-inflammatory drugs [NSAID] (0)
    • Opiods (0)
    • Tender point injections (0)
  • Psychological therapy (0)
    • EMG biofeedback (0)
    • Cognitive therapy (0)
    • Relaxation therapy (0)
    • Hypnosis (0)
  • Alternative therapies (0)
    • Acupuncture (0)
    • Tai Chi (0)
    • Yoga (0)
    • Chiropractic (0)
    • Nutraceuticals and vitamins (0)
    • Herbal therapies (0)
  • Treatment of wrist pain (0)
  • Pharmacologic (0)
    • Analgesics (0)
    • Centrally active anti-depressants (0)
    • Centrally active muscle relaxants (0)
    • Hypnotics (0)
    • Non-steroidal anti-inflammatory drugs [NSAID] (0)
    • Opiods (0)
    • Tender point injections (0)
  • Psychological therapy (0)
    • EMG biofeedback (0)
    • Cognitive therapy (0)
    • Relaxation therapy (0)
    • Hypnosis (0)
  • Alternative therapies (0)
    • Acupuncture (0)
    • Tai Chi (0)
    • Yoga (0)
    • Chiropractic (0)
    • Nutraceuticals and vitamins (0)
    • Herbal therapies (0)
  • Rehabilitation (4)
    • Exercise (2)
      • Exercise for patellar tendinopathy
      • Exercise therapy following surgical rotator cuff repair
    • Physical therapies (1)
      • Rehabilitation after surgery for Dupuytren's Contracture
    • TENS/ALTENS (0)
      • Interferential (0)
    • Laser (0)
    • Massage (1)
      • Deep transverse friction massage for treating lateral elbow or lateral knee tendinitis
    • Patient education (0)
    • Ultrasound (0)
• Spondylo-arthropathy [psoriatic arthritis, ankylosing spondylitis, reactive arthritis] (23)
  • Prevention (0)
  • Treatment (23)
    • Biologics (6)
      • TNF-alpha inhibitors for ankylosing spondylitis
      • Dose reduction and discontinuation of biologic and targeted synthetic disease-modifying anti-rheumatic drugs (DMARDs) in people with axial spondyloarthritis and low disease activity
      • Interleukin inhibitors for psoriatic arthritis
      • Phosphodiesterase 4 inhibitors for psoriatic arthritis
      • TNF-alpha inhibitors for psoriatic arthritis
      • What are the benefits and harms of TNF inhibitors for people with psoriatic arthritis?
    • Analgesics (1)
      • Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
    • Disease modifying antirheumatic drugs (DMARDs) (7)
      • Auranofin (1)
        • Interventions for treating psoriatic arthritis
      • Azathioprine (1)
        • Interventions for treating psoriatic arthritis
      • Methotrexate (4)
        • Dose reduction and discontinuation of biologic and targeted synthetic disease-modifying anti-rheumatic drugs (DMARDs) in people with axial spondyloarthritis and low disease activity
        • Methotrexate for ankylosing spondylitis
        • Methotrexate for psoriatic arthritis
        • Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
      • Sulfasalazine (1)
        • Sulfasalazine for ankylosing spondylitis
    • Colchicine (0)
    • Etretinate (0)
    • Fumaric Acid (2)
      • IMI Gold (1)
        • Interventions for treating psoriatic arthritis
      • Methrotrexate (1)
        • Interventions for treating psoriatic arthritis
    • Intra-articular injections (0)
    • Non-steroidal anti-inflammatory drugs (NSAIDs) (2)
      • Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
      • Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis)
    • Salazopyrin (1)
      • Interventions for treating psoriatic arthritis
    • Alternative therapies (0)
    • Rehabilitation (2)
      • Physiotherapy (1)
        • Physiotherapy interventions for ankylosing spondylitis
      • Exercise (1)
        • Exercise programmes for ankylosing spondylitis
    • Patient education (1)
      • Self management programme for ankylosing spondylitis
    • Selective COX-2 inhibitors (NSAIDs) (1)
      • Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
    • Steroids (0)
• Systemic sclerosis [Raynauds, scleroderma] (11)
  • Prevention (0)
  • Pharmacotherapy (11)
    • Cyclofenil (2)
      • Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis
      • Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol
    • Calcium channel blockers (2)
      • Calcium channel blockers for primary and secondary Raynaud's phenomenon
      • Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol
    • Iloprost (2)
      • Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol
      • Iloprost and cisaprost for Raynaud's phenomenon in progressive systemic sclerosis
    • Ketanserin (2)
      • Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol
      • Ketanserin for Raynaud's phenomenon in progressive systemic sclerosis
    • Prazosin (2)
      • Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol
      • Prazosin for Raynaud's phenomenon in progressive systemic sclerosis
    • Stem cell transplantation (1)
      • Stem cell transplantation for systemic sclerosis
  • Alternative therapies (0)
  • Rehabilitation (0)
    • Exercise (0)
    • Patient education (0)
• Vasculitis [Behcet's, takayasu's arteritis, purpura, schoenlein-henoch, polyarteritis, nodosa, giant cell, arteritis, Wegener's granulomatosis] (10)
  • Prevention (0)
  • Treatment (10)
    • Pharmacological interventions (10)
      • Acyclovir (1)
        • Autologous salive (1)
          • Pharmacotherapy for Behcet's syndrome
      • Azaproprazone (1)
        • Azathioprine (1)
          • Pharmacotherapy for Behcet's syndrome
      • Benzathine penicillin (2)
        • Colchicine (1)
          • Pharmacotherapy for Behcet's syndrome
        • Corticosteroids (1)
          • Pharmacotherapy for Behcet's syndrome
      • Prednisone (1)
        • Cyclosporine (1)
          • Pharmacotherapy for Behcet's syndrome
        • Cyclosphosphamide (0)
      • Topical alpha interpheron (1)
        • Pharmacotherapy for Behcet's syndrome
      • Alternative therapies (0)
      • Rehabilitation (0)
        • Exercise (0)
        • Patient education (0)
      • Drugs (4)
        • Interventions for ganglion cysts in adults
        • Methotrexate for giant cell arteritis
        • Methotrexate for polymyalgia rheumatica
        • Anti-cytokine targeted therapies for ANCA-associated vasculitis