Evidence

Our Reviews

Full list:

By subtopic:

Health conditions older adults (0)
Dietary interventions (0)
Patient education and self-management (0)
Physical activity and exercise (0)
Prevention (0)
Psychological and behavioural interventions (0)
Lupus Erythematosus [systemic, discoid, cutaneous, lupus nephritis] (8)
Prevention (0)
Therapeutic management (efficacy, effectiveness, safety) (7)
Antimalarials (hydroxychloroquine, chloroquine phosphate) (1)
Hydroxychloroquine for systemic lupus erythematosus in adults (protocol stage)
Biologicals (BCell Toleragens) (2)
Disease modifying immunosuppressant drugs for juvenile-onset systemic lupus erythematosus (protocol stage)
Belimumab for systemic lupus erythematosus
Corticosteroids (prednisone, solumedrol) (0)
Herbal (1)
Herbal medicines for systemic lupus erythematosus (protocol stage)
Hormone replacement (1)
Dehydroepiandrosterone for systemic lupus erythematosus
Immunosuppressants (methotrexate, azathioprine, cyclophosphamide (2)
Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus
Disease modifying immunosuppressant drugs for juvenile-onset systemic lupus erythematosus (protocol stage)
Treatment of lupus nephritis (0)
Non-medicinal interventions (1)
Exercise (1)
Exercise as adjunctive therapy for systemic lupus erythematosus (protocol stage)
Patient counseling (0)
Patient education (0)
Psychological interventions (0)
Social support (0)
Diagnostic and prognostic testing (0)
Antinuclear antibodies (0)
Biopsy material (lung, heart, gut, kidney) (0)
Complement testing (0)
Genetic markers (0)
Lymphocyte markers (0)
Rehabilitation (0)
Exercise (0)
Patient education (0)
Alternative therapies (0)
Gout [uric acid, hyperuricemia, pseudogout] (21)
Prevention (0)
Diet (0)
Education (0)
Treatment: chronic (13)
Allopurinol (1)
Allopurinol for chronic gout
Benzbromarone (1)
Uricosuric medications for chronic gout
Biologic (2)
Interleukin-1 inhibitors for acute gout
Pegloticase for chronic gout
Diet (2)
Lifestyle interventions for chronic gout
Lifestyle interventions for acute gout
Dietary supplements (1)
Dietary supplements for chronic gout
Febuxostat (1)
Febuxostat for treating chronic gout
Probenecid (1)
Uricosuric medications for chronic gout
Smoking cessation (2)
Lifestyle interventions for chronic gout
Lifestyle interventions for acute gout
Weight loss (2)
Lifestyle interventions for chronic gout
Lifestyle interventions for acute gout
Treatment: acute (5)
Biologics (1)
Interleukin-1 inhibitors for acute gout
Colchicine (1)
Colchicine for acute gout
Non-drug therapies (0)
Non-steroidal anti-inflammatory drugs (NSAID) (1)
Non-steroidal anti-inflammatory drugs for acute gout
Steroids (2)
Adrenocorticotropic hormone for acute gout (protocol stage)
Systemic corticosteroids for acute gout
Alternative therapies (0)
Rehabilitation (0)
Education (0)
Treatment: tophi gout (3)
Benzbromarone (1)
Interventions for tophi in gout
Probenecid (1)
Interventions for tophi in gout
Surgery (1)
Interventions for tophi in gout
Osteoarthritis (116)
Adherence to treatment (1)
Interventions to improve adherence to exercise for chronic musculoskeletal pain in adults
Prevention (0)
Treatment [Pharmacological interventions] (29)
Analgesia (10)
Acetaminophen for osteoarthritis
Antidepressants for osteoarthritis (protocol stage)
Botulinum toxin for shoulder pain
Chloroquines for the treatment of osteoarthritis (protocol stage)
Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
Oral or transdermal opioids for osteoarthritis of the knee or hip
Paracetamol versus placebo for knee and hip osteoarthritis
Periarticular analgesia for postoperative pain following total hip replacement (protocol stage)
Periarticular analgesia for postoperative pain following total knee replacement (protocol stage)
Tramadol for osteoarthritis
Antibiotics (1)
Doxycycline for osteoarthritis of the knee or hip
Bisphosphonates (1)
Bisphosphonates for osteoarthritis (protocol stage)
Dietary supplements (3)
Chondroitin for osteoarthritis
Glucosamine therapy for treating osteoarthritis
S-Adenosylmethionine for osteoarthritis of the knee or hip
Intra-articular injections (6)
Autologous blood product injections including platelet-rich plasma for osteoarthritis of the knee (protocol stage)
Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
Interventions for treating osteoarthritis of the big toe joint
Intra-articular corticosteroid for knee osteoarthritis
Stem cell injections for osteoarthritis of the knee (protocol stage)
Viscosupplementation for the treatment of osteoarthritis of the knee
Non-steroidal anti-inflammatory drugs (NSAID) (4)
Celecoxib for osteoarthritis
Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
Interventions for treating osteoarthritis of the big toe joint
Rofecoxib for osteoarthritis
Hormone Replacement Therapy (1)
Hormone replacement therapy for osteoarthritis in peri-menopausal and post-menopausal women (protocol stage)
Biologics (0)
Other pharmacological interventions (3)
Diacerein for osteoarthritis
Strontium ranelate for osteoarthritis (protocol stage)
Weight loss for overweight patients with knee or hip osteoarthritis (protocol stage)
Treatment [Non-pharmocological interventions] (50)
Alternative therapies [i.e.acupuncture] (10)
Acupuncture for hip osteoarthritis
Acupuncture for peripheral joint osteoarthritis
Curcuma longa (turmeric) or its active ingredients for osteoarthritis (protocol stage)
Homeopathy for osteoarthritis (protocol stage)
Leeches (Hirudinea) for osteoarthritis (protocol stage)
Oral herbal therapies for treating osteoarthritis
Perioperative interventions for smoking cessation in hip and knee arthroplasty for osteoarthritis and other non-traumatic diseases (protocol stage)
Topical herbal therapies for treating osteoarthritis
Weight loss for overweight patients with knee or hip osteoarthritis (protocol stage)
Yoga for osteoarthritis of the hip or knee (protocol stage)
Balneotherapy (1)
Balneotherapy for osteoarthritis
Laser therapy (1)
Interventions for treating osteoarthritis of the big toe joint
Psychological interventions (1)
Telerehabilitation for hip or knee osteoarthritis (protocol stage)
Surgery (32)
Arthroscopic debridement for knee osteoarthritis
Arthroscopic surgery for degenerative knee disease (osteoarthritis including degenerative meniscal tears)
Cemented versus cementless surgical approach for total hip arthroplasty revision (protocol stage)
Cryotherapy following total knee replacement
Computer assisted knee arthroplasty for osteoarthritis and other non-traumatic diseases (protocol stage)
Effects of different bearing surface materials on aseptic loosening of total hip arthroplasty in patients with osteoarthritis and other non-traumatic diseases of the hip. (protocol stage)
Cemented, cementless or hybrid fixation options in total knee arthroplasty for osteoarthritis and other non-traumatic diseases
Hip resurfacing versus traditional total hip arthroplasty for osteoarthritis and other non-traumatic diseases of the hip (protocol stage)
Mobile bearing vs fixed bearing prostheses for posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients with osteoarthritis and rheumatoid arthritis
Interventions for treating osteoarthritis of the big toe joint
Joint lavage for osteoarthritis of the knee
Metal versus non-metal backing of the tibial component for total knee replacement for osteoarthritis and/or rheumatoid arthritis. (protocol stage)
Minimally invasive surgical approaches for total hip arthroplasty in adults with osteoarthritis (protocol stage)
Osteotomy for treating knee osteoarthritis
Patient-specific cutting guides for total knee arthroplasty (protocol stage)
Periarticular analgesia for postoperative pain following total hip replacement (protocol stage)
Periarticular analgesia for postoperative pain following total knee replacement (protocol stage)
Processed versus fresh frozen bone for impaction bone grafting in revision hip arthroplasty
Psychological therapies for improving outcomes after total hip or knee replacement in people with osteoarthritis and rheumatoid arthritis (protocol stage)
Retention versus sacrifice of the posterior cruciate ligament in total knee arthroplasty for treating osteoarthritis
Shoulder replacement surgery for osteoarthritis and rotator cuff tear arthropathy
Surgery for shoulder osteoarthritis
Surgical approaches in total knee arthroplasty (protocol stage)
Surgical interventions for failed primary knee replacement (protocol stage)
Surgical interventions for symptomatic mild to moderate knee osteoarthritis
Surgical interventions for treating hallux valgus and bunions (protocol stage)
Posterior versus lateral surgical approach for total hip arthroplasty in adults with osteoarthritis
Total hip replacement surgery versus conservative care for hip osteoarthritis and other non-traumatic diseases (protocol stage)
Total joint replacement surgery versus conservative care for knee osteoarthritis and other non-traumatic diseases (protocol stage)
Operative and non-operative treatment options for dislocation of the hip following total hip arthroplasty
Unicompartmental arthroplasty for knee osteoarthritis (protocol stage)
Tourniquet use for knee replacement surgery
TENS (2)
Interventions for treating osteoarthritis of the big toe joint
Transcutaneous electrostimulation for osteoarthritis of the knee
Therapeutic Ultrasound (2)
Interventions for treating osteoarthritis of the big toe joint
Therapeutic ultrasound for osteoarthritis of the knee or hip
Thermotherapy (heat or cold) (1)
Thermotherapy for treatment of osteoarthritis
Rehabilitation (36)
Exercise (12)
Exercise therapy for osteoarthritis (12)
Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee (protocol stage)
Aquatic exercise for the treatment of knee and hip osteoarthritis
High-intensity versus low-intensity physical activity or exercise in people with hip or knee osteoarthritis
Community-based exercise and physical activity programmes led by exercise professionals for osteoarthritis (protocol stage)
Exercise for hand osteoarthritis
Exercise for osteoarthritis of the hip
Exercise for osteoarthritis of the knee
Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
Interventions for treating osteoarthritis of the big toe joint
Home versus center based physical activity programs in older adults
Telerehabilitation for hip or knee osteoarthritis (protocol stage)
Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review
Occupational therapy (1)
Assistive devices, hip precautions, environmental modifications and training to prevent dislocation and improve function after hip arthroplasty
Patient education (4)
Perioperative interventions for smoking cessation in hip and knee arthroplasty for osteoarthritis and other non-traumatic diseases (protocol stage)
Preoperative education for hip or knee replacement
Self-management education programmes for osteoarthritis
Telerehabilitation for hip or knee osteoarthritis (protocol stage)
Continuous Passive Motion (1)
Continuous passive motion following total knee arthroplasty in people with arthritis
Modalities (5)
Surface neuromuscular electrical stimulation for quadriceps strengthening pre and post total knee replacement
Electromagnetic fields for treating osteoarthritis
Interventions for treating osteoarthritis of the big toe joint
Isokinetic exercise for improving knee flexor and extensor muscles (protocol stage)
Traction for hip osteoarthritis (protocol stage)
Physiotherapy (4)
Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
Post-acute physiotherapy for primary total hip arthroplasty (protocol stage)
Post-acute physiotherapy for primary total knee arthroplasty (protocol stage)
Taping for knee osteoarthritis (protocol stage)
Splints/Orthoses (5)
Braces and orthoses for treating osteoarthritis of the knee
Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
Interventions for treating osteoarthritis of the big toe joint
Shoe and heel lifts for leg length inequality in adults with musculoskeletal conditions (protocol stage)
Taping for knee osteoarthritis (protocol stage)
Multidisciplinary rehabilitation (1)
Multidisciplinary rehabilitation programmes following joint replacement at the hip and knee in chronic arthropathy
Tai Chi (2)
Exercise for osteoarthritis of the hip
Exercise for osteoarthritis of the knee
Telerehabilitation (1)
Telerehabilitation versus conventional face-to-face land-based exercises following hip or knee arthroplasty (protocol stage)
Osteoporosis [premenopausal, post-menopausal, corticosteroid induced, osteoporosis in men ] (49)
Prevention (9)
Diet (5)
Pharmacological interventions for preventing bone density loss in critically ill people (protocol stage)
Phytoestrogens in the treatment of postmenopausal osteoporosis (protocol stage)
Vitamin D supplementation for improving bone mineral density in children
Vitamin D supplementation in infancy for improving bone density (protocol stage)
Calcium and vitamin D for increasing bone mineral density in premenopausal women (protocol stage)
Education (0)
Exercise (4)
Exercise for preventing and treating osteoporosis in postmenopausal women
Exercise for preventing low bone mass in young males and females (protocol stage)
Physical activity for preventing or managing osteoporosis in men (protocol stage)
Whole body vibration for preventing and treating osteoporosis (protocol stage)
Treatment [non-pharmacological] (6)
Herbal (1)
Chinese herbal medicines for treating osteoporosis
Rehabilitation (4)
Exercise (3)
Exercise for improving outcomes after osteoporotic vertebral fracture
Exercise for preventing and treating osteoporosis in postmenopausal women
Whole body vibration for preventing and treating osteoporosis (protocol stage)
Modalities (0)
Patient education (1)
Preoperative education for hip or knee replacement
Surgery (1)
Percutaneous vertebroplasty for osteoporotic vertebral compression fracture
Treatment [pharmacological agents] (34)
Anti-sclerostin antibodies (1)
Anti-sclerostin antibodies for the treatment of osteoporosis (protocol stage)
Bisphosphonates (9)
Bisphosphonates (5)
Bisphosphonate therapy for children and adolescents with secondary osteoporosis
Bisphosphonates for steroid-induced osteoporosis
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Pharmacological interventions for preventing bone density loss in critically ill people (protocol stage)
Pharmacological therapies for the prevention of fractures in men (protocol stage)
Alendronate (1)
Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
Clodronate (0)
Etidronate (1)
Etidronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
Ibandronate (0)
Risedronate (1)
Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
Zolendronate (1)
Intravenous zoledronate for postmenopausal osteoporosis (protocol stage)
Denosumab (2)
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Pharmacological therapies for the prevention of fractures in men (protocol stage)
Pamidronate (1)
Zolendronate (1)
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Calcium (2)
Calcium supplementation for improving bone mineral density in children
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Calcium and Vitamin D in combination (2)
Calcium and vitamin D for corticosteroid-induced osteoporosis
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Calcitonin (2)
Calcitonin for preventing and treating corticosteroid-induced osteoporosis
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Fluoride (1)
Fluoride for treating postmenopausal osteoporosis
Growth hormone (0)
Hormone replacement therapy (0)
Selective estrogen receptor modulators (SERMS) (6)
Bazedoxifene (1)
Selective estrogen receptor modulators for preventing and treating postmenopausal osteoporosis (protocol stage)
Lasofoxifene (1)
Selective estrogen receptor modulators for preventing and treating postmenopausal osteoporosis (protocol stage)
Nandrolone decanoate (1)
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Raloxifene (2)
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Selective estrogen receptor modulators for preventing and treating postmenopausal osteoporosis (protocol stage)
Tibolone (1)
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Ipriflavone (0)
Parathyroid hormone (4)
Human parathyroid hormone for preventing and treating glucocorticoid-induced osteoporosis (protocol stage)
Human parathyroid hormone for the treatment of osteoporosis in post-menopausal women (protocol stage)
Pharmacologic interventions for preventing and treating periprosthetic osteoporosis following total hip arthroplasty (protocol stage)
Pharmacological therapies for the prevention of fractures in men (protocol stage)
Statins (1)
Statins for osteoporosis in postmenopausal women (protocol stage)
Vitamin D (1)
Vitamin D with or without calcium for treating osteoporosis in postmenopausal women (protocol stage)
Calcitriol (0)
Cholecalciferol (0)
Alternative therapies (0)
Strontium ralenate (1)
Strontium ranelate for preventing and treating postmenopausal osteoporosis
Vitamin K (1)
Vitamin K for the prevention and treatment of osteoporosis in post-menopausal women (protocol stage)
Other reviews (3)
Canadian C-spine rule and the National Emergency X-Radiography Utilization Study (NEXUS) for detecting clinically important cervical spine injury following blunt trauma (protocol stage)
COVID-19 vaccination for people with autoimmune inflammatory rheumatic diseases on immunomodulatory therapies (protocol stage)
Models of care for managing non-specific low back pain (protocol stage)
Pediatric Rheumatology [juvenile rheumatoid] (8)
Pharmacological interventions (6)
Biologics (2)
Dose reduction and discontinuation of disease-modifying anti-rheumatic drugs (DMARDs) for juvenile idiopathic arthritis (protocol stage)
TNF-alpha inhibitors for juvenile idiopathic arthritis (protocol stage)
Methotrexate (2)
Dose reduction and discontinuation of disease-modifying anti-rheumatic drugs (DMARDs) for juvenile idiopathic arthritis (protocol stage)
Methotrexate for treating juvenile idiopathic arthritis
Other Pharmacological interventions (2)
Corticosteroids for septic arthritis in children
Intravenous immunoglobulin for juvenile idiopathic arthritis (protocol stage)
Rehabilitation (2)
Exercise (1)
Exercise therapy in juvenile idiopathic arthritis
Patient education (0)
Splints/Rest (1)
Intra-articular steroids and splints/rest for children with juvenile idiopathic arthritis and adults with rheumatoid arthritis
Alternative therapies (0)
Legg Perthes (1)
Surgical management (1)
Surgical management of Perthes disease (protocol stage)
Paget's Disease (1)
Bisphosphonates for Paget's disease of bone in adults
Physical activity (4)
Exercise (3)
Exercise for acutely hospitalised older medical patients
Exercise therapy following surgical rotator cuff repair (protocol stage)
Mobility training for increasing mobility and functioning in older people with frailty (protocol stage)
Mental health (1)
Exercise for positive mental health outcomes in adults (protocol stage)
Reactive arthritis (2)
Treatment - Pharmacological (2)
Antibiotics for reactive arthritis (protocol stage)
Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Rheumatoid Arthritis (87)
Prevention (1)
COVID19 (0)
Cardiovascular complications (1)
Hypolipidemic and antihypertensive drugs for prevention of cardiovascular complications in patients with rheumatoid arthritis (protocol stage)
Diet (0)
Periodontal disease (0)
Nonpharmacologic (30)
Assistive Technology (1)
Assistive technology for rheumatoid arthritis
Diet (2)
Marine oil supplements for rheumatoid arthritis (protocol stage)
Dietary interventions for rheumatoid arthritis
Exercise (3)
Balance training (proprioceptive training) for patients with rheumatoid arthritis
Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis
Home-based exercise therapy for rheumatoid arthritis (protocol stage)
Nonpharmacologic (1)
Non-pharmacological interventions for fatigue in rheumatoid arthritis
Surgery (4)
Cemented, cementless or hybrid fixation options in total knee arthroplasty for osteoarthritis and other non-traumatic diseases
Hip resurfacing versus traditional total hip arthroplasty for osteoarthritis and other non-traumatic diseases of the hip (protocol stage)
Mobile bearing vs fixed bearing prostheses for posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients with osteoarthritis and rheumatoid arthritis
Surgical interventions for the rheumatoid shoulder
Alternative therapies (i.e. acupuncture) (3)
Ayurveda interventions for rheumatoid arthritis (protocol stage)
Herbal therapy for treating rheumatoid arthritis
Tai Chi for rheumatoid arthritis
Rehabilitation (16)
Occupational Therapy (2)
Occupational therapy for rheumatoid arthritis
Splints and Orthosis for treating rheumatoid arthritis
Physical Therapy (14)
Exercise (5)
Aquatic therapy exercise for treating rheumatoid arthritis (protocol stage)
Comprehensive physiotherapy for rheumatoid arthritis (protocol stage)
Cyclophosphamide for treating rheumatoid arthritis
Exercise for rheumatoid arthritis of the hand
Post-operative therapy for metacarpophalangeal arthroplasty
Thermotherapy (1)
Thermotherapy for treating rheumatoid arthritis
Balneotherapy (1)
Balneotherapy (or spa therapy) for rheumatoid arthritis
Electrotherapy (5)
Acupuncture and electroacupuncture for the treatment of rheumatoid arthritis
Therapeutic ultrasound for the treatment of rheumatoid arthritis
Low level laser therapy (Classes I, II and III) for treating rheumatoid arthritis
Electrical stimulation for the treatment of rheumatoid arthritis
Transcutaneous electrical nerve stimulation (TENS) for the treatment of rheumatoid arthritis in the hand
Education (2)
Patient education for adults with rheumatoid arthritis
Self-management education programmes for rheumatoid arthritis (protocol stage)
exercise (0)
Treatment [Pharmacological interventions] (56)
Biologics (18)
Abatacept for rheumatoid arthritis
Adalimumab for treating rheumatoid arthritis
Anakinra for rheumatoid arthritis
Baricitinib for rheumatoid arthritis (protocol stage)
Biologic interventions for fatigue in rheumatoid arthritis
Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis
Biologics for rheumatoid arthritis: an overview of Cochrane reviews
Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA)
Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis
Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis
Certolizumab pegol (CDP870) for rheumatoid arthritis in adults
Golimumab for rheumatoid arthritis
Down-titration and discontinuation strategies of tumour necrosis factor–blocking agents for rheumatoid arthritis in patients with low disease activity
Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis
Ofatumumab for rheumatoid arthritis (protocol stage)
Rituximab for rheumatoid arthritis
Adverse effects of biologics: a network meta-analysis and Cochrane overview
Tocilizumab for rheumatoid arthritis
Disease modifying antirheumatic drugs (DMARDs), also slow acting antirheumatic drugs; second line agents (SAARDs) (17)
Iguratimod (0)
Methotrexate (5)
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis
Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis
Methotrexate for treating rheumatoid arthritis
Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Subcutaneous or intramuscular methotrexate for rheumatoid arthritis (protocol stage)
Gold, auranofin, myochrisine, solgonal (2)
Auranofin versus placebo in rheumatoid arthritis
Injectable gold for rheumatoid arthritis
Hydroxychloroquine (2)
Antimalarials for treating rheumatoid arthritis
Disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a systematic review and network meta-analysis (protocol stage)
Chloroquine (1)
Antimalarials for treating rheumatoid arthritis
Azathioprine (1)
Azathioprine for treating rheumatoid arthritis
Cyclosphosphamide (1)
Cyclophosphamide for treating rheumatoid arthritis
Cyclosporine (1)
Cyclosporine for treating rheumatoid arthritis
Leflunomide (1)
Leflunomide for the treatment of rheumatoid arthritis
Nitrogen Mustard (0)
Mycophenolic acid (0)
Sulfasalazine (1)
Sulfasalazine for treating rheumatoid arthritis
Antimicrobial (0)
Eythropoietin (1)
Erythropoiesis-stimulating agents for anemia in rheumatoid arthritis
Penicillamine (1)
Penicillamine for treating rheumatoid arthritis
Intra-articular injections (0)
Non-biologics (1)
Non-biologic pharmaceutical interventions for fatigue in rheumatoid arthritis (protocol stage)
Steroids (4)
Effects of glucocorticoids on radiological progression in rheumatoid arthritis
Long-term glucocorticoids for rheumatoid arthritis (protocol stage)
Short-term glucocorticoids for flares in people with rheumatoid arthritis receiving disease-modifying anti-rheumatic drugs (DMARDs) (protocol stage)
Short-term induction glucocorticoids and disease-modifying anti-rheumatic drugs (DMARD) therapy for rheumatoid arthritis (protocol stage)
Symptom modifying anti-rheumatic drugs (SMARDs) (16)
Non-steroidal anti-inflammatory drugs (NSAIDs) (2)
Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Paracetamol versus nonsteroidal anti-inflammatory drugs for rheumatoid arthritis
Selective Cox 2 inhibitors (NSAIDs) (3)
Celecoxib for rheumatoid arthritis
Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Rofecoxib for rheumatoid arthritis
Analgesics (7)
Antidepressants for pain management in rheumatoid arthritis
Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Muscle relaxants for pain management in rheumatoid arthritis
Neuromodulators for pain management in rheumatoid arthritis
Opioid therapy for treating rheumatoid arthritis pain
Pain management for inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and other spondyloarthritis) and gastrointestinal or liver comorbidity
Pain management for rheumatoid arthritis and cardiovascular or renal comorbidity
Corticosteroids (2)
Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis
Moderate-term, low-dose corticosteroids for rheumatoid arthritis
Fish Oil (0)
Radiation synovectomy (0)
Yttrium90 (0)
Biologics (2)
AntiCD4, Anti TNF (2)
Etanercept for the treatment of rheumatoid arthritis
Infliximab for the treatment of rheumatoid arthritis
Analgesics for chronic, not acute rheumatoid arthritis (0)
Bone marrow transplant (0)
Stem cell transplant (0)
Steroids (0)
Disease controlling antirheumatic therapy (DCARTs only) (0)
Sjogren's syndrome (1)
Treatment (1)
Biologics (1)
Disease-modifying anti-rheumatic drugs (DMARDs) for Sjogren’s syndrome (protocol stage)
Corticosteroids (0)
Non-pharmacological interventions (0)
Soft tissue [rheumatism, rheumatic disease, bursitis, tendonitis] (78)
Prevention (1)
Kinesio taping for rotator cuff disease
Treatment of Fibromyalgia (14)
Acupuncture for treating fibromyalgia
Aerobic exercise training for adults with fibromyalgia
Amitriptyline for fibromyalgia in adults
Amitriptyline for neuropathic pain in adults
Aquatic exercise training for fibromyalgia
Cognitive behavioural therapies for fibromyalgia syndrome
Combinations of drugs versus single drugs to treat fibromyalgia pain in adults
Exercise for treating fibromyalgia syndrome
Flexibility exercise training for adults with fibromyalgia
Mixed exercise training for adults with fibromyalgia
Multidisciplinary rehabilitation for fibromyalgia and musculoskeletal pain in working age adults
NSAIDs, analgesics and opioids agents for fibromyalgia syndrome (protocol stage)
Resistance exercise training for fibromyalgia
Whole body vibration exercise training for fibromyalgia
Pharmacologic (7)
Analgesics (0)
Centrally active anti-depressants (3)
Anti-depressants and centrally active agents for fibromyalgia syndrome (protocol stage)
Selective serotonin reuptake inhibitors for fibromyalgia syndrome
Serotonin and noradrenaline reuptake inhibitors for fibromyalgia
Centrally active muscle relaxants (0)
Hypnotics (0)
Non-steroidal anti-inflammatory drugs [NSAID] (1)
Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger
Opiods (0)
Tender point injections (0)
Other (3)
Botulinum toxin for shoulder pain
Topical glyceryl trinitrate for rotator cuff disease
Topical glyceryl trinitrate for lateral elbow pain (protocol stage)
Non-pharmacologic (4)
Surgery (3)
Surgery for treating hip impingement (femoroacetabular impingement)
Surgery for patellar tendinopathy (jumper’s knee)
Surgical treatment for advanced stage of avascular necrosis of the femoral head in adults (protocol stage)
Exercise (1)
Stretch for the treatment and prevention of contractures
Psychological therapy (2)
EMG biofeedback (0)
Cognitive therapy (1)
Mind and body therapy for fibromyalgia
Relaxation therapy (1)
Mind and body therapy for fibromyalgia
Hypnosis (0)
Alternative therapies (2)
Acupuncture (1)
Acupuncture for treating fibromyalgia
Tai Chi (1)
Mind and body therapy for fibromyalgia
Yoga (0)
Chiropractic (0)
Nutraceuticals and vitamins (0)
Herbal therapies (0)
Treatment of shoulder pain (19)
Pharmacologic (4)
Analgesics (0)
Centrally active anti-depressants (0)
Centrally active muscle relaxants (0)
Hypnotics (0)
Non-steroidal anti-inflammatory drugs [NSAID] (0)
Opiods (0)
Tender point injections (3)
Corticosteroid injections for shoulder pain
Hyaluronate for shoulder osteoarthritis (protocol stage)
Image-guided glucocorticoid injection versus injection without image guidance for shoulder pain
Other (1)
Oral steroids for adhesive capsulitis
Psychological therapy (0)
EMG biofeedback (0)
Cognitive therapy (0)
Relaxation therapy (0)
Hypnosis (0)
Non-pharmacologic (10)
Surgery (2)
Surgery for rotator cuff tears
Subacromial decompression surgery for rotator cuff disease
Rehabilitation (8)
Acupuncture for shoulder pain
Arthrographic distension for adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for rotator cuff disease
Manual therapy and exercise for adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for rotator cuff disease
Shock wave therapy for rotator cuff disease with or without calcification
Physiotherapy interventions for shoulder pain
Alternative therapies (5)
Acupuncture (5)
Electrotherapy modalities for adhesive capsulitis (frozen shoulder)
Electrotherapy modalities for rotator cuff disease
Manual therapy and exercise for adhesive capsulitis (frozen shoulder)
Manual therapy and exercise for rotator cuff disease
Physiotherapy interventions for shoulder pain
Tai Chi (0)
Yoga (0)
Chiropractic (0)
Nutraceuticals and vitamins (0)
Herbal therapies (0)
Treatment of elbow pain (12)
Pharmacologic (4)
Analgesics (0)
Centrally active anti-depressants (0)
Centrally active muscle relaxants (0)
Hypnotics (0)
Non-steroidal anti-inflammatory drugs [NSAID] (1)
Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults
Opioids (0)
Tender point injections (3)
Autologous blood and platelet-rich plasma injection therapy for lateral elbow pain
Botulinum toxin injection for tennis elbow (protocol stage)
Corticosteroid injections for tennis elbow (protocol stage)
Non-pharmacologic (7)
Orthotics (1)
Orthotic devices for the treatment of tennis elbow
Physiotherapy (4)
Electrotherapy modalities for lateral elbow pain (protocol stage)
Manual therapy and exercise for lateral elbow pain (protocol stage)
Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults
Physiotherapy and physiotherapeutical modalities for lateral epicondylitis (protocol stage)
Surgery (1)
Surgery for lateral elbow pain
Shock wave therapy (1)
Shock wave therapy for lateral elbow pain
Psychological therapy (0)
EMG biofeedback (0)
Cognitive therapy (0)
Relaxation therapy (0)
Hypnosis (0)
Alternative therapies (1)
Acupuncture (1)
Acupuncture for lateral elbow pain
Tai Chi (0)
Yoga (0)
Chiropractic (0)
Nutraceuticals and vitamins (0)
Herbal therapies (0)
Rehabilitation (0)
Treatment of knee pain (2)
Pharmacologic (0)
Analgesics (0)
Centrally active anti-depressants (0)
Centrally active muscle relaxants (0)
Hypnotics (0)
Non-steroidal anti-inflammatory drugs [NSAID] (0)
Opiods (0)
Tender point injections (0)
Psychological therapy (0)
EMG biofeedback (0)
Cognitive therapy (0)
Relaxation therapy (0)
Hypnosis (0)
Alternative therapies (1)
Acupuncture (0)
Tai Chi (0)
Yoga (0)
Chiropractic (0)
Nutraceuticals and vitamins (0)
Herbal therapies (0)
Rehabilitation (1)
Deep transverse friction massage for treating lateral elbow or lateral knee tendinitis
Surgery (1)
Surgery for patellar tendinopathy (jumper’s knee)
Treatment of ankle pain (0)
Pharmacologic (0)
Analgesics (0)
Centrally active anti-depressants (0)
Centrally active muscle relaxants (0)
Hypnotics (0)
Non-steroidal anti-inflammatory drugs [NSAID] (0)
Opiods (0)
Tender point injections (0)
Psychological therapy (1)
EMG biofeedback (0)
Cognitive therapy (0)
Relaxation therapy (1)
Mind and body therapy for fibromyalgia
Hypnosis (0)
Alternative therapies (0)
Acupuncture (0)
Tai Chi (0)
Yoga (0)
Chiropractic (0)
Nutraceuticals and vitamins (0)
Herbal therapies (0)
Treatment of foot pain (5)
Custom-made foot orthoses for the treatment of foot pain
Foot orthoses for treating paediatric flat feet
Interventions for pes planus (protocol stage)
Shockwave therapy for plantar heel pain (plantar fasciitis) (protocol stage)
Shoe and heel lifts for leg length inequality in adults with musculoskeletal conditions (protocol stage)
Pharmacologic (0)
Analgesics (0)
Centrally active anti-depressants (0)
Centrally active muscle relaxants (0)
Hypnotics (0)
Non-steroidal anti-inflammatory drugs [NSAID] (0)
Opiods (0)
Tender point injections (0)
Interventions (0)
Psychological therapy (0)
EMG biofeedback (0)
Cognitive therapy (0)
Relaxation therapy (0)
Hypnosis (0)
Alternative therapies (0)
Acupuncture (0)
Tai Chi (0)
Yoga (0)
Chiropractic (0)
Nutraceuticals and vitamins (0)
Herbal therapies (0)
Treatment of hand pain (4)
Non-pharmacological (2)
Rehabilitation (0)
Surgery (2)
Surgery for Dupuytren's contracture of the fingers
Surgery for trigger finger
Pharmacological (2)
Corticosteroid injection for de Quervain's tenosynovitis
Corticosteroid injection for trigger finger in adults
Pharmacologic (0)
Analgesics (0)
Centrally active anti-depressants (0)
Centrally active muscle relaxants (0)
Hypnotics (0)
Non-steroidal anti-inflammatory drugs [NSAID] (0)
Opiods (0)
Tender point injections (0)
Psychological therapy (0)
EMG biofeedback (0)
Cognitive therapy (0)
Relaxation therapy (0)
Hypnosis (0)
Alternative therapies (0)
Acupuncture (0)
Tai Chi (0)
Yoga (0)
Chiropractic (0)
Nutraceuticals and vitamins (0)
Herbal therapies (0)
Treatment of hip pain (1)
Interventions for lateral hip pain (tendinopathy or bursitis) (protocol stage)
Pharmacologic (0)
Analgesics (0)
Centrally active anti-depressants (0)
Centrally active muscle relaxants (0)
Hypnotics (0)
Non-steroidal anti-inflammatory drugs [NSAID] (0)
Opiods (0)
Tender point injections (0)
Psychological therapy (0)
EMG biofeedback (0)
Cognitive therapy (0)
Relaxation therapy (0)
Hypnosis (0)
Alternative therapies (0)
Acupuncture (0)
Tai Chi (0)
Yoga (0)
Chiropractic (0)
Nutraceuticals and vitamins (0)
Herbal therapies (0)
Treatment of wrist pain (0)
Pharmacologic (0)
Analgesics (0)
Centrally active anti-depressants (0)
Centrally active muscle relaxants (0)
Hypnotics (0)
Non-steroidal anti-inflammatory drugs [NSAID] (0)
Opiods (0)
Tender point injections (0)
Psychological therapy (0)
EMG biofeedback (0)
Cognitive therapy (0)
Relaxation therapy (0)
Hypnosis (0)
Alternative therapies (0)
Acupuncture (0)
Tai Chi (0)
Yoga (0)
Chiropractic (0)
Nutraceuticals and vitamins (0)
Herbal therapies (0)
Rehabilitation (4)
Exercise (2)
Exercise for patellar tendinopathy (protocol stage)
Exercise therapy following surgical rotator cuff repair (protocol stage)
Physical therapies (1)
Rehabilitation after surgery for Dupuytren's Contracture (protocol stage)
TENS/ALTENS (0)
Interferential (0)
Laser (0)
Massage (1)
Deep transverse friction massage for treating lateral elbow or lateral knee tendinitis
Patient education (0)
Ultrasound (0)
Spondylo-arthropathy [psoriatic arthritis, ankylosing spondylitis, reactive arthritis] (21)
Prevention (0)
Treatment (21)
Biologics (5)
TNF-alpha inhibitors for ankylosing spondylitis
Interleukin inhibitors for psoriatic arthritis (protocol stage)
Phosphodiesterase 4 inhibitors for psoriatic arthritis (protocol stage)
TNF-alpha inhibitors for psoriatic arthritis (protocol stage)
Tumor necrosis factor (TNF) inhibitors for the treatment of psoriatic arthritis (protocol stage)
Analgesics (1)
Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Disease modifying antirheumatic drugs (DMARDs) (6)
Auranofin (1)
Interventions for treating psoriatic arthritis
Azathioprine (1)
Interventions for treating psoriatic arthritis
Methotrexate (3)
Methotrexate for ankylosing spondylitis
Methotrexate for psoriatic arthritis
Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Sulfasalazine (1)
Sulfasalazine for ankylosing spondylitis
Colchicine (0)
Etretinate (0)
Fumaric Acid (2)
IMI Gold (1)
Interventions for treating psoriatic arthritis
Methrotrexate (1)
Interventions for treating psoriatic arthritis
Intra-articular injections (0)
Non-steroidal anti-inflammatory drugs (NSAIDs) (2)
Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis)
Salazopyrin (1)
Interventions for treating psoriatic arthritis
Alternative therapies (0)
Rehabilitation (2)
Physiotherapy (1)
Physiotherapy interventions for ankylosing spondylitis
Exercise (1)
Exercise programmes for ankylosing spondylitis
Patient education (1)
Self management programme for ankylosing spondylitis (protocol stage)
Selective COX-2 inhibitors (NSAIDs) (1)
Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Steroids (0)
Systemic sclerosis [Raynauds, scleroderma] (11)
Prevention (0)
Pharmacotherapy (11)
Cyclofenil (2)
Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis
Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol (protocol stage)
Calcium channel blockers (2)
Calcium channel blockers for primary and secondary Raynaud's phenomenon
Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol (protocol stage)
Iloprost (2)
Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol (protocol stage)
Iloprost and cisaprost for Raynaud's phenomenon in progressive systemic sclerosis
Ketanserin (2)
Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol (protocol stage)
Ketanserin for Raynaud's phenomenon in progressive systemic sclerosis
Prazosin (2)
Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol (protocol stage)
Prazosin for Raynaud's phenomenon in progressive systemic sclerosis
Stem cell transplantation (1)
Stem cell transplantation for systemic sclerosis (protocol stage)
Alternative therapies (0)
Rehabilitation (0)
Exercise (0)
Patient education (0)
Vasculitis [Behcet's, takayasu's arteritis, purpura, schoenlein-henoch, polyarteritis, nodosa, giant cell, arteritis, Wegener's granulomatosis] (10)
Prevention (0)
Treatment (10)
Pharmacological interventions (10)
Acyclovir (1)
Autologous salive (1)
Pharmacotherapy for Behcet's syndrome
Azaproprazone (1)
Azathioprine (1)
Pharmacotherapy for Behcet's syndrome
Benzathine penicillin (2)
Colchicine (1)
Pharmacotherapy for Behcet's syndrome
Corticosteroids (1)
Pharmacotherapy for Behcet's syndrome
Prednisone (1)
Cyclosporine (1)
Pharmacotherapy for Behcet's syndrome
Cyclosphosphamide (0)
Topical alpha interpheron (1)
Pharmacotherapy for Behcet's syndrome
Alternative therapies (0)
Rehabilitation (0)
Exercise (0)
Patient education (0)
Drugs (4)
Interventions for ganglion cysts in adults (protocol stage)
Methotrexate for giant cell arteritis (protocol stage)
Methotrexate for polymyalgia rheumatica (protocol stage)
Anti-cytokine targeted therapies for ANCA-associated vasculitis