For Systematic Review Authors

How a review develops in a collaborative review group...

The Review Author contacts the Cochrane Review Group relevant to his/ her area of interest and/or the systematic review they wish to undertake. Following discussion with the Coordinating Editors and Managing Editors, he or she decides upon an appropriate title. The review author can check the titles that have already been registered by authors interested in developing a review. 

The 7 steps of preparing and maintaining a systematic review:
(Outlined in the Cochrane Handbook)

1. Formulating a problem
2. Locating and selecting studies
3. Critical appraisal of studies
4. Collecting data
5. Analyzing and presenting results
6. Interpreting results
7. Improving and updating reviews

Proposed Outcomes for CMSG Reviews

Review Proposal 

Cochrane invites prospective authors to propose new Cochrane Reviews by submitting a proposal in Editorial Manager. Please see the Cochrane Library information for authors for further details.

Once submitted the proposal is circulated to members of Cochrane (Fields, Networks, international centers and other collaborative review groups) to guard against possibility of overlap. If the proposal is successful, then review proposal becomes a registered title. 

All Cochrane Musculoskeletal reviews should adhere to the MECIR standards.  

Protocol Development

Following title registration, the review author begins work on a protocol. The protocol is probably the most important aspect of a review. The completed protocol will provide the template that will guide the completion of the review and subsequent updates. It is the protocol that ensures transparency and accountability. Feedback from the editorial board of the review group is supplied at each draft, with specialist statistical advice brought in where necessary. Publication of the protocol on the Cochrane Library follows approval by the Group's editorial board, feedback from two External Referees and final approval by the Coordinating Editor.

A protocol template is uploaded to RevMan as soon as your title is registered. It contains the recommended options, and presents some methodological choices for the authors. 

A Cochrane Protocol Contains...

  • Background

  • Objectives

  • Criteria for considering studies for this review

  • Types of studies

  • Types of participants

  • Types of interventions

  • Types of outcome measures (Click here to see a list of proposed outcomes)

  • Search strategy for identification of studies

  • Methods of the review

  • Selection of trials

  • Assessment of risk of bias

  • Data management and extraction

  • Data synthesis

Review Development and Review Publication and Updates

After submission and publication of the review protocol, the authors begin carrying out the review according to the methods established in the protocol. There are many resources available to CMSG review authors to help them with all steps involved, such as assessing the risk of bias of included studies and presenting the findings effectively.

Completed reviews are put through an internal and external review process to ensure quality and rigor prior to submission for publication. Following approval and publication, reviews are ideally updated at least every 2 years in order to keep the review up-to-date with the most recent evidence.

For a complete information package describing the process of writing a review, click here. You can download Review Manager 5 (RevMan 5) here

First Steps

The primary contact person for the review should liaise with the managing editor while developing their review. The managing editor will be able to provide details of the support and resources available from the CMSG (such as technical assistance and methodological advice including help with developing search strategies and the use of CMSG data collection checklists, which describe the inclusion criteria for studies, quality issues, the collection of relevant data, etc).

Study selection

For all CMSG reviews, 'a priori' peer reviewed protocols are produced prior to submission of the review to the Cochrane Library. The inclusion and exclusion criteria are established and at least two authors carry out the selection process for included studies. If consensus is not reached, a third review author is assigned.

Assessment of risk of bias

The CMSG requires an assessment of the risk of bias of included studies. 

The CMSG editorial team encourages review authors to use the Cochrane Collaboration's Risk of Bias tool, which is neither a scale nor a checklist. This tool is a domain-based evaluation, in which critical assessments are made separately for six different domains: sequence generation; allocation concealment; blinding of participants, personnel and outcome assessors; incomplete outcome data; selective outcome reporting; and 'other sources of bias'. The Risk of Bias tool is described in more detail in chapter 8 of The Cochrane Handbook.

Grading of Evidence

Methods for grading the scientific evidence have evolved over the past decade as evidence-based health care has become increasingly important in clinical practice. All Cochrane Musculoskeletal reviews use the 'Grading of Recommendation Assessment Development and Evaluation' (GRADE) approach (GRADEpro GDT 2015) to summarize the overall strength, or grading, of the evidence for each major outcome included in a review. This grading system specifies four levels of quality: high, moderate, low, and very low. The highest quality rating is for a body of evidence based on randomized trials without important limitations.

Review authors can downgrade randomized trial evidence depending on the presence of five factors (study limitations, inconsistency of results, indirectness of evidence, imprecision and publication bias) and upgrade the quality of evidence of observational studies depending on three factors (large magnitude of effect, plausible confounding, which would reduce a demonstrated effect, and dose-response gradient).

The GRADE approach is described in more detail in chapter 14 of The Cochrane Handbook.

Summary of Findings Tables

The CM editorial team now recommends the use of Summary of Findings tables to present results in reviews. These replace clinical relevance tables that were previously used. The summary of findings table provides key information concerning the quality of evidence, the magnitude of effect of the interventions examined, and the sum of available data on all important outcomes for a given comparison. For dichotomous outcomes, the absolute risk reduction and the relative risk reduction should be provided and for those outcomes that are statistically significant, the number needed to treat should be calculated. A maximum of seven important outcomes including benefit and harm outcomes should be identified early in the review development process; if possible, during the review proposal stage. When review authors do not include information on these important outcomes in the review they should say so.

CMSG summary of findings table guidelines are available here.

Data collection

It is the Musculoskeletal Group's policy to recommend that at least two authors independently select the studies, assess the methodological quality and extract the data. Data collection forms should be used on all CMSG reviews. At the editorial office we have developed a number of data collection forms that can be modified for each of the reviews. 


CM also has statistical advisers who will work closely with all CM authors to provide ongoing statistical guidance for completion of their Cochrane reviews. For statistical guidelines used by the Musculoskeletal Group, please refer to the Cochrane Handbook or contact the editorial office.

Reporting of reviews

The CM editorial team is supportive of authors who wish to submit their review to a paper-based journal prior to or simultaneous to submission to the Cochrane Library. Agreements vary depending on the number of modifications and timing for publication in those journals. Please contact the managing editor if you plan to do this. Indeed, the CM has an agreement with the Journal of Rheumatology and selected CMSG reviews will be considered for co-publication in this journal. When publishing in the Journal of Rheumatology, it is the authors' responsibility to reformat their review accordingly and cover the expenses requested by the journal.

Reviews and the Peer-review process

All submitted reviews are peer reviewed by at least two internal members of the editorial team and two external peer referees. At least one external referee is a consumer. The CMSG consumer members have developed a consumer checklist with which the reviews are assessed. Again, the coordinating office compiles the comments received from the various peer reviewers and a summary is sent to the author. The final copy-editing prior to submission to the Cochrane Library is done at the coordinating office. Once a review is submitted the author has up to two years to submit an updated review, depending on the extent of the review.

Please contact the editorial base if you are interested in updating a review. 

Once the updated review has been submitted, it will again be subject to the editorial process and copy-editing as outlined in the Editorial Publishing Policy Resource